References

References:

ac-11:

  • Sheng, Y et al. “Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa.”Journal of ethnopharmacology 69,2 (2000): 115-26. doi:10.1016/s0378-8741(99)00070-7
  • Emanuel, Patrick, and Noah Scheinfeld. “A review of DNA repair and possible DNA-repair adjuvants and selected natural anti-oxidants.”Dermatology online journal  13,3 10. 13 Jul. 2007
  • Akesson, Christina et al. “An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death.”International immunopharmacology  3,13-14 (2003): 1889-900. doi:10.1016/j.intimp.2003.07.001

Hobamine:

  • Rathmacher JA, Fuller JC Jr, Abumrad NN, Flynn CR. Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humans. Inflammation. 2023 Mar 20:1–10. doi: 10.1007/s10753-023-01801-w. Epub ahead of print. PMID: 36935449; PMCID: PMC10025056.
  • May-Zhang, Linda S et al. “Scavenging Reactive Lipids to Prevent Oxidative Injury.”Annual review of pharmacology and toxicology 61 (2021): 291-308. doi:10.1146/annurev-pharmtox-031620-035348
  • Wu, Jing et al. “Immune activation caused by vascular oxidation promotes fibrosis and hypertension.”The Journal of clinical investigation  126,1 (2016): 50-67. doi:10.1172/JCI80761

Ergothioneine:

  • Tian, X., Thorne, J., & Moore, J. (2023). Ergothioneine: An underrecognised dietary micronutrient required for healthy ageing? British Journal of Nutrition, 129(1), 104-114. doi:10.1017/S0007114522003592
  • Halliwell, Barry et al. “Ergothioneine - a diet-derived antioxidant with therapeutic potential.”FEBS letters  592,20 (2018): 3357-3366. doi:10.1002/1873-3468.13123
  • Cheah, Irwin K, and Barry Halliwell. “Ergothioneine, recent developments.”Redox biology  42 (2021): 101868. doi:10.1016/j.redox.2021.101868
  • Watanabe N,Matsumoto S, Suzuki M, Fukaya T, Kato Y, Hashiya N. Effect of ergothioneine on the cognitive function improvement in healthy volunteers and mild cognitive impairment subjects–A randomized, double-blind, parallel-group comparison study. Jpn Pharmacol Ther. 2020;48:685–97.
  • Apparoo, Yasaaswini et al. “Ergothioneine and its prospects as an anti-ageing compound.”Experimental gerontology  170 (2022): 111982. doi:10.1016/j.exger.2022.111982
  • Samuel, Priscilla et al. “Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions.”Journal of dietary supplements  19,2 (2022): 212-225. doi:10.1080/19390211.2020.1854919
  • Smith E, Ottosson F, Hellstrand S, et al
  • Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease Heart 2020;106:691-697.

Spermidine:

  • Hofer, S.J., Simon, A.K., Bergmann, M. et al. Mechanisms of spermidine-induced autophagy and geroprotection. Nat Aging (2022). https://doi.org/10.1038/s43587-022-00322-9
  • Madeo, Frank et al. “Spermidine in health and disease.” Science (New York, N.Y.) 359,6374 (2018): eaan2788. doi:10.1126/science.aan2788
  • Ghosh, Indrani et al. “Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders.” Neuropeptides 83 (2020): 102083. doi:10.1016/j.npep.2020.102083
  • Madeo, Frank et al. “Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans.” Autophagy 15,1 (2019): 165-168. doi:10.1080/15548627.2018.1530929
  • Eisenberg, Tobias et al. “Cardioprotection and lifespan extension by the natural polyamine spermidine.” Nature medicine 22,12 (2016): 1428-1438. doi:10.1038/nm.4222
  • Minois N, Carmona-Gutierrez D, Madeo F. Polyamines in aging and disease. Aging (Albany NY). 2011 Aug;3(8):716-32. doi: 10.18632/aging.100361. PMID: 21869457; PMCID: PMC3184975.

Sulforaphane:

  • Vanduchova, Alena et al. “Isothiocyanate from Broccoli, Sulforaphane, and Its Properties.”Journal of medicinal food  22,2 (2019): 121-126. doi:10.1089/jmf.2018.0024
  • Houghton, Christine A. “Sulforaphane: Its "Coming of Age" as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease.”Oxidative medicine and cellular longevity  2019 2716870. 14 Oct. 2019, doi:10.1155/2019/2716870
  • Kaiser, Anna E et al. “Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential.”Cancers  13,19 4796. 25 Sep. 2021, doi:10.3390/cancers13194796
  • Yuanfeng, Wu et al. “Approaches for enhancing the stability and formation of sulforaphane.”Food chemistry  345 (2021): 128771. doi:10.1016/j.foodchem.2020.128771

Pyrroloquinoline quinone (PQQ):

  • Jonscher, Karen R et al. “Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention.” Biomolecules vol. 11,10 1441. 30 Sep. 2021, doi:10.3390/biom11101441
  • Akagawa, Mitsugu et al. “Recent progress in studies on the health benefits of pyrroloquinoline quinone.” Bioscience, biotechnology, and biochemistry vol. 80,1 (2016): 13-22. doi:10.1080/09168451.2015.1062715
  • Saihara, Kazuhiro et al. “Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway.” Biochemistry vol. 56,50 (2017): 6615-6625. doi:10.1021/acs.biochem.7b01185
  • Tamakoshi, Masanori et al. “Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults.” Food & function vol. 14,5 2496-2501. 6 Mar. 2023, doi:10.1039/d2fo01515c

Buckwheat peptides:

  • Zhou, X., Wen, L., Li, Z.et al. Advance on the benefits of bioactive peptides from buckwheat. Phytochem Rev 14, 381–388 (2015). https://doi.org/10.1007/s11101-014-9390-0
  • Fan Zhu. "Buckwheat Proteins and Peptides: Biological Functions and Food Applications."Trends in food science & technology, v. 110 ,. pp. 155-167. doi: 1016/j.tifs.2021.01.081

AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing astragaloside I, II, IV and ginsenoside Rb1:

  • Zhou P, Xie W, Sun Y, Dai Z, Li G, Sun G, Sun X. Ginsenoside Rb1 and mitochondria: A short review of the literature. Mol Cell Probes. 2019 Feb;43:1-5. doi: 10.1016/j.mcp.2018.12.001. Epub 2018 Dec 4. Erratum in: Mol Cell Probes. 2020 Dec;54:101626. PMID: 30529056.
  • Chang, Tsu-Chung et al. “Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression.” Journal of agricultural and food chemistry vol. 55,5 (2007): 1993-8. doi:10.1021/jf062714k
  • Wang, Chun-Wen et al. “A gut microbial metabolite of ginsenosides, compound K, induces intestinal glucose absorption and Na(+) /glucose cotransporter 1 gene expression through activation of cAMP response element binding protein.” Molecular nutrition & food research vol. 59,4 (2015): 670-84. doi:10.1002/mnfr.201400688
  • Liang, Yutong et al. “Pharmacological Effects of Astragaloside IV: A Review.” Molecules (Basel, Switzerland) vol. 28,16 6118. 18 Aug. 2023, doi:10.3390/molecules28166118
  • Zhou, Ping et al. “Ginsenoside Rb1 and mitochondria: A short review of the literature.” Molecular and cellular probes vol. 43 (2019): 1-5. doi:10.1016/j.mcp.2018.12.001