Prime Strength+

OUT OF STOCK. ALL ORDERS SHIPPING WEEK OF 6/29

Muscle performance depends on the signal that triggers synthesis, the energy to sustain it, and the purity of what you put into your body to support it. Prime Strength+ was designed to optimize all three.*

Most muscle formulas choose between performance ingredients and quality standards. Prime Strength+ combines both: DL185™ dileucine — the next-generation leucine dipeptide absorbed 185% faster than free leucine — alongside PeptiStrong®'s three-trial validated AI-discovered peptides, and Pürest Creatine® — the world's first creatine monohydrate to achieve "not detected" status for both DHT and DCD, the two most concerning contaminants in conventional creatine.*

KEY SUPPORTED BENEFITS

Prime Strength+ is formulated to support:*

• Healthy muscle protein synthesis and lean muscle maintenance*
• Muscle strength, power, and performance output during resistance training*
• Post-exercise recovery, reduced muscle soreness, and faster strength restoration*
• Cellular energy production (ATP) for sustained training performance*
• Healthy muscle protein turnover — synthesis support and anti-catabolic signaling*
• Gut integrity and immune resilience in the context of high training demand*
• Hydration, electrolyte balance, and healthy muscle contraction*
• Long-term muscle fiber quality — both Type I endurance and Type II power fibers*

THE FIVE-INGREDIENT MUSCLE PERFORMANCE SYSTEM

• Next-Generation Anabolic Signaling → DL185™ Dileucine (PEPT1-mediated · 185% faster · 2024 human trial)
• AI-Discovered Precision Peptides → PeptiStrong® (3 human RCTs · 19.7% strength gain) 
• Pharmaceutical-Grade Cellular Energy → Pürest Creatine® (zero DHT · zero DCD) 
• Gut Integrity & Recovery Support → L-Glutamine (mucosal barrier · muscle recovery · immune resilience)
• Hydration & Antioxidant Defense → Taurine (electrolyte balance · muscle contraction · oxidative protection)

THE FORMULA

DL185™ Dileucine (L-Leucyl-L-Leucine Monohydrate)

Role: Next-Generation mTOR Activation via PEPT1-Mediated Rapid Absorption 

DL185™ is a patented leucine dipeptide — two L-leucine molecules enzymatically bonded together — that represents a fundamental advancement in how the body receives and uses leucine for muscle protein synthesis.*

The problem with free leucine: single amino acids are absorbed through competitive amino acid transporter systems that become saturated at high concentrations. Multiple amino acids compete for the same transporters, slowing absorption and limiting peak plasma leucine levels. Additionally, achieving the dose of dileucine found in a 2g serving of DL185™ through dietary protein alone would require consuming approximately 159g of whey protein concentrate or 219g of pea protein — making concentrated supplementation the only practical clinical path.*

How DL185™ works differently:

PEPT1 Transporter Advantage: Dileucine is absorbed intact through the high-capacity PEPT1 (peptide transporter 1) system in the small intestine — a dedicated dipeptide transport pathway that operates independently from amino acid competition and has high transport capacity. Research confirms dipeptides are absorbed approximately 185% faster than their equivalent free amino acids through this mechanism — the source of the "185" in DL185™.*

Dual Anabolic Signal: A meaningful fraction of dileucine reaches systemic circulation intact as the dipeptide — not fully hydrolyzed in the gut — creating two distinct anabolic signals simultaneously: elevated plasma dileucine and elevated free leucine from hydrolysis. This dual signal may explain the superior mTOR activation observed in research.*

Intracellular Leucine Amplification: Once inside muscle cells, dileucine is hydrolyzed to leucine intracellularly — rapidly elevating intracellular leucine concentrations that activate the mTORC1 signaling cascade, the master regulator of muscle protein synthesis, mitochondrial biogenesis, and cellular repair.*

Superior mTOR Activation: Controlled studies show dileucine produces stronger phosphorylation of mTOR and downstream effectors S6K1 and 4E-BP1 compared to equimolar free leucine — suggesting greater anabolic signaling efficiency per gram administered.*

Clinical Evidence — DL185™:*

• Double-blind, randomized, placebo-controlled trial (PLoS One, December 2024): dileucine ingestion, but not leucine at the same dose, produced statistically significant improvements in lower body strength and performance following resistance training — leucine produced no significant changes*
• Resistance training protocol: 4 sessions per week, all major muscle groups, 3–4 sets at 6–10 reps*
• Researchers concluded dileucine's superior PEPT1-mediated absorption and intracellular delivery produced meaningfully different outcomes than equivalent leucine*
• Absorption kinetics study: dileucine reaches peak plasma concentrations 185% faster than free leucine, with greater total leucine availability in blood and higher intramuscular leucine concentrations*

Age-relevance note: the PEPT1 advantage becomes even more pronounced in aging muscle. Gut absorption efficiency and intestinal blood flow both decline with age, making free amino acid transport less reliable over time. PEPT1 is a high-capacity system that is less susceptible to age-related decline — making DL185™ particularly relevant for older patients where declining amino acid absorption efficiency contributes to anabolic resistance.*

PeptiStrong® (Vicia faba / Fava Bean Protein Hydrolysate)

Dose: 2.4 g Role: Multi-Pathway Muscle Protein Synthesis, Anti-Catabolic & Recovery Support Discovered by Nuritas Magnifier™ AI Platform

PeptiStrong® is a network of cell-signaling peptides identified within fava bean protein hydrolysate by Nuritas's Magnifier™ AI platform — screened from over 2 million candidate peptide sequences and selected for their ability to activate mTOR-related muscle protein synthesis pathways, suppress muscle catabolism, and survive gastrointestinal digestion intact.*

Three completed, peer-reviewed human clinical trials — all at the 2.4g dose used in Prime Strength+:*

Study 1 — Immobilization & Muscle Protein Synthesis (Maastricht University, Journal of Nutrition, 2023):*

• 30 healthy young men: short-term leg immobilization followed by remobilization
• PeptiStrong® preserved muscle mass during immobilization comparable to milk protein
• PeptiStrong® significantly outperformed milk protein in muscle protein synthesis rate during the recovery and remobilization phase — plant-derived peptides at 2.4g exceeding the anabolic gold standard*

Study 2 — Strength Recovery & Fatigue (Nutrients, 2023):*

• Exercise-induced muscle damage protocol (DOMS)
• Significant improvement in strength recovery versus placebo
• Significant reduction in muscle fatigue following exercise
• Significant suppression of plasma myostatin — the primary protein inhibitor of muscle growth
• Researchers concluded PeptiStrong® "significantly improves strength recovery and restoration, reduces fatigue, and positively modulates markers related to muscle homeostasis"*

Study 3 — Strength, Bone Density & Endurance (Nuritas, 2024):*

• 56-day supplementation, mixed male and female population ages 19–40
• 19.7% greater increase in muscle strength versus placebo
• 1% increase in bone density in 56 days — clinically relevant for perimenopausal women and aging patients*
• Improvements in muscular endurance alongside strength*

Comparative data (Nuritas, 2024): as effective as leucine at 25% of the typical leucine dose; 60% more effective than HMB at half the usual dose; matches creatine in ATP synthesis with 5x superior mTOR upregulation.*

Key mechanisms:*

• mTOR/mTORC1 pathway activation for muscle fiber regeneration and protein synthesis*
• Myostatin suppression — reducing the primary brake on muscle growth*
• Anti-catabolic signaling: downregulation of atrophy-related genes MuRF1 and Atrogin-1*
• AMPK activation supporting mitochondrial energy metabolism*
• Type I and Type II muscle fiber support — endurance and power simultaneously*
• Plant-sourced · non-GMO · self-affirmed GRAS · Health Canada approved

Powered by Nuritas. [Learn more about our Nuritas partnership →]

Pürest Creatine® (Creatine Monohydrate)

Role: ATP Regeneration, Strength, Power & Pharmaceutical-Grade Purity 

Creatine monohydrate is the most researched ingredient in sports nutrition history — with decades of peer-reviewed human studies demonstrating its role in supporting ATP regeneration, muscle strength, power output, and recovery. The science on creatine is settled. What has not been settled — until now — is the purity question.*

The creatine purity problem: conventional creatine manufacturing generates three concerning byproducts that are present in virtually all commercially available creatine, including many premium and German-sourced products:

Dihydrotriazine (DHT): a heterocyclic compound structurally similar to triazine herbicides. The European Food Safety Authority (EFSA) recommends a maximum of 3 mg/kg. Generic Chinese creatine has been found at over 110 mg/kg — 37x the EFSA limit. Even premium German-sourced creatine has been measured at approximately 20 mg/kg — still nearly 7x the EFSA recommended ceiling. DHT is considered the most concerning creatine contaminant due to its structural similarity to suspected carcinogens.*

Dicyandiamide (DCD): a manufacturing byproduct forming when cyanamide molecules react with each other instead of with sarcosine. EFSA maximum is 50 mg/kg. Generic creatine has been found exceeding 100 mg/kg. Premium German creatine stays under the limit, but DCD remains detectable.*

Creatinine: creatine's thermal degradation product — elevated levels indicate high-temperature manufacturing or poor storage. EFSA guideline: ≤100 mg/kg.*

Why Pürest Creatine® is different: NNB Nutrition's proprietary synthesis process prevents DHT and DCD formation at the source — rather than filtering after production, the manufacturing pathway itself avoids the reaction conditions that generate these byproducts. The result:*

• DHT: Not Detected — below the detection threshold of validated analytical methods*
• DCD: Not Detected — the industry's first creatine to achieve this standard*
• Creatinine: significantly lower than both generic and premium German creatine sources*
• Every production lot: independently third-party tested with transparent certificates of analysis*
• Vegan · allergen-free · non-GMO · micronized for superior dissolution*

The clinical significance: when creatine is used daily — as it should be for sustained performance benefits — impurity exposure accumulates proportionally with dose. For practitioners recommending creatine to longevity-focused patients using it long-term, Pürest Creatine® eliminates exposure to the contaminants that have historically been an accepted if undesirable feature of the ingredient category.*

For performance: creatine monohydrate supports phosphocreatine resynthesis in muscle — the immediate ATP regeneration system that powers the first 10–15 seconds of maximal effort. Consistent creatine supplementation supports greater training volume, improved 1RM strength, faster recovery between sets, and over time, greater lean mass accrual from resistance training.*

L-Glutamine

Role: Gut Barrier Integrity, Muscle Recovery & Immune Resilience During Training

Glutamine is the most abundant amino acid in the body and a conditionally essential amino acid during periods of high physiological stress — including intense exercise, which rapidly depletes muscle glutamine stores.*

In the context of Prime Strength+, glutamine serves three distinct and complementary roles:

Gut barrier support: Glutamine is the primary fuel source for enterocytes — the cells lining the intestinal wall. During intense training, gut blood flow is diverted to working muscle, creating oxidative stress and permeability risk in the gut epithelium. Glutamine supplementation supports gut barrier integrity during this window — reducing the intestinal permeability that can drive systemic inflammation and impair recovery.*

Muscle recovery support: Glutamine is a substrate for muscle protein synthesis and contributes to nitrogen balance during recovery. It supports the cellular environment needed for glycogen resynthesis and tissue repair following intense training.*

Immune resilience: Intense exercise temporarily suppresses immune function — partly through glutamine depletion. Glutamine is a preferred fuel for immune cells including lymphocytes and macrophages, and maintaining glutamine availability supports healthy immune function during high training volumes.*

Taurine

Role: Cellular Hydration, Electrolyte Balance & Antioxidant Protection During Exercise

Taurine is a sulfonic acid found in high concentrations in skeletal muscle, heart, and brain — where it serves as an osmolyte regulating cell volume and intracellular ion balance. During exercise, taurine supports cellular hydration and electrolyte balance — maintaining optimal muscle cell volume for contraction efficiency and reducing cramping risk.*

Taurine's antioxidant and membrane-stabilizing properties provide direct protection against exercise-induced oxidative stress in muscle tissue — supporting the intracellular environment in which PeptiStrong® and DL185™'s anabolic signals operate.*

Research also demonstrates taurine supports healthy mitochondrial function and fatty acid oxidation — adding a cellular energy dimension to its primary role in hydration and muscle protection.*

HOW TO USE

Mixing Instructions: Mix 1 serving (1 scoop) with 8–12 oz of water, juice, or your preferred beverage. Consume once daily. May also be mixed into your protein shake or pre/post-workout beverage for convenience.

Timing: For muscle protein synthesis support, consume within 30–60 minutes post-exercise. On non-training days, consume in the morning with breakfast.