Mitochondria Prime+™

Advanced Mitochondrial Healthspan Support

ATP Production • Redox Balance • Cellular Renewal†

Every hallmark of aging converges on one organelle. Mitochondria Prime+™ was built to support all the ways it declines.*

Mitochondria are not merely energy producers. They are the cellular command centers for metabolic flexibility, redox signaling, apoptosis regulation, and the integration of internal and external stress signals. When mitochondrial function declines — as it does progressively with age — the downstream consequences span every tissue and system: reduced energy output, impaired cognitive clarity, slower muscle recovery, diminished immune resilience, and accelerated cellular aging across the board.

Mitochondria Prime+™ addresses mitochondrial health through three non-redundant pillars — Power, Protect, and Renew — with seven clinically studied ingredients targeting the distinct and interconnected mechanisms that determine how well mitochondria function, how long they survive, and how effectively they are renewed.*

KEY SUPPORTED BENEFITS

Mitochondria Prime+™ is formulated to support:*

• Healthy cellular ATP production and mitochondrial energy efficiency*
• Mitochondrial renewal and mitophagy-related cellular housekeeping*
• Redox balance and endogenous antioxidant defense — Nrf2, glutathione, and beyond*
• Cell membrane stability and mitochondrial resilience against oxidative stress*
• Cognitive clarity, focus, and neuronal energy metabolism*
• Muscle performance, endurance, and post-exercise recovery*
• Healthy fatty acid transport and utilization for cellular energy production*
• Long-term cellular vitality and healthspan signaling*

THE THREE-PILLAR MITOCHONDRIAL HEALTHSPAN SYSTEM

• Power → Acetyl-L-Carnitine + Riboflavin-5'-Phosphate (fatty acid transport, electron transport chain)
• Protect → Algevity® + MitoPrime® + Astaxanthin + Selenium (Nrf2, redox defense, membrane integrity)
• Renew → Naturalin™ Pro ( direct urolithin delivery + ellagic acid precursor)

THE FORMULA — SEVEN INGREDIENTS. THREE BIOLOGICAL PILLARS.

PILLAR ONE: POWER

Supporting Cellular Energy Production and Mitochondrial Efficiency

Acetyl-L-Carnitine HCl (ALCAR)

Dose: 750 mg Role: Fatty Acid Transport & Neuronal Energy Metabolism

Acetyl-L-Carnitine is the acetylated form of L-Carnitine — uniquely positioned to cross the blood-brain barrier and support neuronal energy metabolism alongside its primary role in mitochondrial fatty acid transport.*

ALCAR's central function in mitochondrial bioenergetics is the transport of long-chain fatty acids across the inner mitochondrial membrane and into the mitochondrial matrix, where they undergo beta-oxidation to generate acetyl-CoA for ATP production.* Without sufficient carnitine, fatty acid oxidation slows and mitochondrial energy output declines — a process that accelerates with age as endogenous carnitine biosynthesis decreases.*

The acetyl group on ALCAR provides a second mechanism: acetylcholine precursor support in neuronal tissue, contributing to neurotransmitter synthesis and supporting the cognitive energy metabolism that underpins mental clarity, focus, and neuroprotection.*

ALCAR's clinical evidence across aging adults supports its role in maintaining cognitive function, reducing mental fatigue, and supporting neuronal energy metabolism — making it the essential bioenergetics foundation of Mitochondria Prime+™.*

Riboflavin-5'-Phosphate Sodium (Active B2)

Dose: 50 mg Role: Electron Transport Chain Cofactor & Mitochondrial Energy Pathway Support

Riboflavin (Vitamin B2) is an essential mitochondrial cofactor — specifically as the precursor to FAD (flavin adenine dinucleotide) and FMN (flavin mononucleotide), the two coenzymes that serve as critical electron carriers in the mitochondrial electron transport chain.* Without adequate FAD and FMN, electron flow through Complex I and Complex II stalls and ATP production drops.*

Mitochondria Prime+™ uses riboflavin-5'-phosphate — the bioactive, phosphorylated form of B2 that is already in the activated cofactor state, bypassing the conversion step required for standard riboflavin. This is particularly meaningful for patients with riboflavin kinase enzyme variations that limit conventional riboflavin activation, and for ensuring consistent electron transport chain support regardless of individual metabolic variation.*

At 50 mg — significantly above the standard RDA — Mitochondria Prime+™ delivers riboflavin at a dose designed to meaningfully support electron transport chain function in a clinical context, not merely prevent deficiency.*

PILLAR TWO: PROTECT

Redox Defense, Nrf2 Pathway Support & Membrane Integrity

Algevity® (Ulva lactuca Supercritical CO₂ Extract)

Dose: 300 mg Role: Nrf2-Mediated Cellular Defense & Upstream Redox Protection Healthgevity Exclusive

Algevity® is a supercritical CO₂ extract of Ulva lactuca — a green marine algae selected from a screening of 30 marine algae species as the most potent activator of the Nrf2-ARE pathway identified in that analysis.*

The Nrf2 (Nuclear factor erythroid 2-related factor 2) pathway is the body's master switch for endogenous antioxidant defense — when activated, Nrf2 translocates to the nucleus, binds the Antioxidant Response Element (ARE), and upregulates over 200 cytoprotective genes, including:*

• NQO1 (NAD(P)H:quinone oxidoreductase 1)*
• Heme oxygenase-1 (HO-1)*
• Thioredoxin reductase 1*
• Glutamate-cysteine ligase (both subunits) — the rate-limiting enzyme in glutathione synthesis*
• The cystine/glutamate exchange transporter*

Published research in Free Radical Biology and Medicine identified three monounsaturated fatty acid (MUFA) derivatives from Ulva lactuca — including a novel keto-type C18 fatty acid — as the active Nrf2 activators, showing ARE-activating effects in human neuroblastoma cells and significant induction of Nrf2-driven cytoprotective genes in vivo.*

Ulva lactuca also provides sulfated polysaccharides (ulvans) that support healthy inflammatory signaling, mitochondrial function support, and gut microbiome balance.*

Supercritical CO₂ extraction preserves thermolabile bioactive compounds that would be destroyed by conventional solvent or heat-based extraction — delivering the full bioactive profile of Ulva lactuca in a concentrated, clean extract.*

Algevity® is a Healthgevity Exclusive — this ingredient at this extraction standard is not available in retail or general practitioner-channel supplements.*

MitoPrime® L-Ergothioneine

Dose: 25 mg Role: "The Longevity Vitamin" — Selective Cellular Antioxidant Accumulation & Mitochondrial Resilience 

L-Ergothioneine is a unique dietary amino acid — a sulfur-containing thiohistidine betaine found in the highest concentrations in mushrooms — that three major scientific reviews published in 2022, 2023, and 2024 have elevated from "interesting antioxidant" to what many researchers now characterize as a "longevity vitamin" essential for healthy aging.*

What makes L-Ergothioneine biologically distinct from conventional antioxidants:

Dedicated transporter-mediated tissue accumulation: L-Ergothioneine is actively transported into cells and tissues via a dedicated transporter protein (OCTN1/SLC22A4) — one found in tissues with the highest metabolic activity and oxidative demand, including red blood cells, liver, kidney, brain, and eyes. Rather than being uniformly distributed or rapidly excreted, ergothioneine accumulates precisely where antioxidant protection is needed most.*

Longest half-life of known oral antioxidants: Unlike most dietary antioxidants that are rapidly metabolized and excreted, ergothioneine is retained by the body with an exceptionally long half-life — functioning as a standing reserve of antioxidant protection rather than a time-limited acute effect.*

Mitochondrial uptake: Research demonstrates that ergothioneine is taken up and accumulated by mitochondria — with uptake occurring even in isolated mitochondria independent of the cell-surface transporter — positioning it directly at the site of highest oxidative stress in the cell.*

Declining levels with age and cognitive implications: Ergothioneine plasma levels decline measurably with age. Emerging research associates lower ergothioneine levels with reduced cognitive reserve and impaired mitochondrial function. Higher dietary ergothioneine intake has been associated with longer healthspan in population-level analyses.*

MitoPrime® is a pharmaceutical-grade, fermentation-derived L-Ergothioneine from NNB Nutrition — delivering the pure L-isomer at a dose that mirrors the research literature supporting its longevity and mitochondrial protection applications.*

The 2024 review published in Protein & Cell, alongside 2022 and 2023 reviews in peer-reviewed journals, collectively support ergothioneine's role in supporting mitochondrial function, cellular redox homeostasis, anti-inflammatory signaling, and healthy aging across multiple tissue systems.*

Astaxanthin

Dose: 12 mg Role: Membrane-Integrated Antioxidant & Mitochondrial Membrane Resilience

Astaxanthin is a xanthophyll carotenoid that occupies a unique structural position in cell biology: its polar end groups span both the intracellular and extracellular faces of lipid bilayer membranes simultaneously — providing antioxidant protection across the entire membrane thickness, not just at the surface.*

This membrane-spanning architecture makes astaxanthin unusually effective at protecting cell membranes and mitochondrial membranes from lipid peroxidation — the chain-reaction oxidative damage to membrane fatty acids that impairs mitochondrial function and cellular integrity.*

Astaxanthin is documented to be 550 times more potent as a singlet oxygen quencher than Vitamin E and 6,000 times more potent than Vitamin C — though these comparisons reflect specific mechanisms rather than overall antioxidant equivalence. More clinically relevant: astaxanthin crosses the blood-brain barrier and the blood-retinal barrier, providing antioxidant protection in neuronal and retinal tissue where oxidative stress is particularly consequential.*

The 12 mg dose in Mitochondria Prime+™ is in the upper range of doses used in human clinical trials demonstrating benefits for oxidative stress markers, cognitive performance, and exercise recovery — ensuring meaningful mitochondrial and cellular membrane protection at a clinically relevant level.*

Selenium as L-Selenomethionine

Dose: 100 mcg Role: Glutathione Peroxidase & Antioxidant Enzyme System Support

Selenium is the essential mineral cofactor for glutathione peroxidase (GPx) — one of the primary enzymatic antioxidant defense systems that neutralizes hydrogen peroxide and lipid hydroperoxides before they can damage cellular components and mitochondrial membranes.*

Without adequate selenium, GPx activity declines and the cellular redox burden increases — a compounding problem in the context of aging-related oxidative stress. L-Selenomethionine is the most bioavailable organic form of selenium, with significantly higher absorption and tissue retention compared to inorganic selenium sources (selenate or selenite).*

Selenium also supports the deiodinase enzymes that activate thyroid hormone — adding a metabolic and energy regulation dimension to its antioxidant role.*

At 100 mcg, Mitochondria Prime+™ delivers selenium at the upper end of the optimal intake range — supporting glutathione peroxidase activity without approaching the upper tolerable intake level.*

PILLAR THREE: RENEW

Mitochondrial Renewal and Cellular Longevity Signaling

Naturalin™ Pro

Dose: 700 mg total (Naturalin®  + Urolithin A + Urolithin B) Role: Direct Urolithin Delivery, Mitophagy-Related Mitochondrial Renewal & Precursor Pathway Support Healthgevity Exclusive

Naturalin™ Pro is a three-component mitochondrial renewal complex — the only formulation in the Healthgevity catalog that delivers both direct urolithin supplementation and a highly bioavailable ellagic acid precursor simultaneously.*

Most urolithin supplements rely entirely on the gut microbiome to convert ellagitannins or ellagic acid into urolithins — a conversion that varies dramatically between individuals. Research shows that only approximately one-third of adults have the gut microbiome composition to efficiently produce Urolithin A from dietary precursors. The remaining two-thirds produce little to none, regardless of how much pomegranate or ellagic acid they consume. Naturalin™ Pro bypasses this limitation entirely by delivering Urolithin A and Urolithin B directly — ensuring meaningful urolithin exposure regardless of individual microbiome composition.*

Urolithin A is the most extensively studied urolithin metabolite in longevity science. Published human clinical evidence — including the landmark double-blind, placebo-controlled trial in older adults by Amazentis (published in Nature Metabolism) — demonstrates that oral Urolithin A supplementation supports mitophagy-related pathways, increases muscle mitochondrial gene expression, and improves physical performance in aging adults.*

Mitophagy is the selective cellular process that identifies and removes damaged or dysfunctional mitochondria before they can generate excess reactive oxygen species, impair ATP production, or trigger apoptotic signaling. Declining mitophagy efficiency with age is one of the primary mechanisms driving deterioration in mitochondrial quality — and Urolithin A's ability to support this process is what distinguishes it as a genuine longevity ingredient rather than simply an antioxidant.*

Urolithin B —  Urolithin B is a structurally distinct urolithin metabolite of growing research interest — particularly for its role in supporting muscle protein synthesis signaling and inhibiting the proteasomal degradation of muscle proteins.* Urolithin B has been shown in preclinical studies to activate androgen receptor-mediated pathways involved in muscle maintenance — a complementary mechanism to Urolithin A's mitophagy support that together address both the energy quality and the structural integrity of aging muscle tissue.*

The inclusion of Urolithin B alongside Urolithin A in Naturalin™ Pro reflects the emerging understanding that the urolithin family exerts complementary rather than redundant effects — making a combined formulation more comprehensive than single-urolithin approaches.*

Naturalin® — 100 mg (Halo Life Science) The third component is Naturalin® — Halo Life Science's patented choline salt of ellagic acid, which is over 1,000 times more soluble than conventional ellagic acid. As a highly bioavailable precursor to urolithins, Naturalin® supports ongoing microbiome-mediated urolithin production between doses — sustaining urolithin availability through the conversion pathway alongside the directly delivered Urolithin A and Urolithin B.*

Naturalin® also provides GLUT4 signaling support, alpha-glucosidase inhibition, and antioxidant defense through ellagic acid's independent bioactivities — adding metabolic and redox dimensions to the purely mitochondrial renewal focus of the urolithin components.*

Naturalin™ Pro is a Healthgevity Exclusive formulation — this three-component urolithin + precursor system is not available in retail or general practitioner-channel supplements.*

WHY SEVEN INGREDIENTS AT THESE DOSES

Most mitochondrial supplements rely on CoQ10, alpha lipoic acid, or NAD+ precursors — addressing one or two pathways at the surface level. Mitochondria Prime+™ was built differently.

ALCAR and Riboflavin-5'-Phosphate support the energy production infrastructure — the electron transport chain and fatty acid oxidation machinery that generates ATP.*

Algevity® activates the Nrf2 master switch — upregulating the body's own endogenous antioxidant defense network across over 200 cytoprotective genes, rather than simply supplementing individual antioxidants.*

MitoPrime® accumulates in the mitochondria and tissues that need it most — providing standing antioxidant protection with the longest half-life of any known oral antioxidant.*

Astaxanthin integrates into mitochondrial membranes — protecting the lipid bilayer structures that determine membrane potential and electron transport chain function.*

Selenium provides the essential cofactor for glutathione peroxidase — the enzymatic defense system that neutralizes peroxides before they damage mitochondrial components.*

Naturalin™ Pro supports mitophagy-related renewal — ensuring that damaged mitochondria are cleared and renewed, maintaining the quality of the mitochondrial population over time.*

This is a systems-level formula. Power, protect, and renew — simultaneously.*