Telomere Prime+

As the science of longevity continues to evolve, more and more researchers are focusing on geroprotectors- compounds capable to have the potential to prevent or even reverse aging at the cellular level.  Telomere Prime reflects cutting-edge science, featuring a broad spectrum of ingredients that have been shown to support healthy cellular function.  The health of our cells is foundational to our overall health, so supporting our health and vitality is one of the smartest things we can do for our long-term wellbeing.  The compounds in Telomere Prime have been carefully chosen for their ability to protect and repair DNA, reduce telomere shortening and support healthy cellular function.  Telomere Prime supports genomic stability and other key indicators of healthspan and lifespan such as, antioxidant protection, body global cell health, inflammation support, and mitochondrial function.

Featured Benefits: 

• Support the body’s natural ability to repair its own DNA. 
• Significantly increases telomere length in yearlong clinical trials. 
• Inhibit synthesis of pro-inflammatory “inflammaging” cytokines such as interleukin (IL)-6, (IL)-8, NF-KB and TNF-alpha. 
• Prevent cell death through inhibition of the pro-apoptotic factors. 
• Support your DNA’s defenses against free radical damage and activates NRF2
• Activates the cell and mitochondrial renewal process
• Chelate divalent metal ions. 
• Protect against damage caused by the prooxidants ferric-NTA and β-amyloid. 
• Enhance the immune system by increasing the life cycle of white blood cells. 
• Helps reduce DNA and mitochondrial damage and protect against free radicals. 
• Protect against UV and gamma radiation by neutralizing radiation-induced reactive oxygen species (ROS). 

ac-11® Cat's Claw Aqueous Extract (Uncaria tomentosa)

ac-11® is an all-natural, safe, and effective aqueous extract of Uncaria tomentosa, a medicinal plant indigenous to the Amazon rainforest. Manufactured using a proprietary process, this extract provides a broad spectrum of health benefits, primarily directed towards systemic DNA repair, environmental stress, infection, immunosenescence and aging. 

Scientists have determined that when the body is subjected to external stressors such as overexposure to the Sun (UV radiation), strenuous exercise, pollution, and/or the general effects of aging, our DNA is damaged. Such cumulative DNA damage has been scientifically confirmed as a causative factor in the age-onset disease. 

In a series of peer-reviewed scientific and clinical studies conducted by third-party laboratories and university medical centers, ac-11® has been proven to help the body’s natural ability to repair its own DNA. The primary active ingredients of ac-11® are formed by the complex molecular chains known as CAEs (Carboxy Alkyl Esters). CAEs are responsible for approximately 90% of ac-11®’s therapeutic benefits. Studies demonstrate that this patented technology: 

• Increases telomere length in a cell (Patent No.: US 10,098,922B1)
• Helps the body’s natural ability to repair its own DNA 
• Enhances the immune system by increasing the life cycle of white blood cells
• Repairs neural function damaged by overexposure to high decibel noise
• Helps to normalize the expression of NF-KB, thereby regulating the cellular response to systemic inflammation
• Maintains telomere length and integrity during the process of cellular mitosis 
• Increases production of natural collagen III, a form of collagen associated with soft, supple, youthful-looking skin 

ac-11® differs from all other Uncaria tomentosa extracts, most of which are sold under the common name “cat’s claw,” in that its molecular composition is distinct. Such distinction is achieved through an ultra-filtration process that produces a low weight (less than 10,000 Daltons) bioavailable, scientifically indole alkaloid free (less than 0.05 ppm) extract.   The inner bark of the plant (Uncaria tomentosa) used to manufacture ac-11® is harvested in the Amazon rainforests of Brazil and Peru utilizing an eco-friendly and renewable process.  

2-HOBA (as Hobamine®)

Hobamine™, or 2-hydroxybenzylamine (2-HOBA), is a naturally occurring compound in Himalayan Tartary Buckwheat that is at the forefront of new developments to support cellular health, particularly as we age. Hobamine™ (2-HOBA) works by rapidly capturing specific reactive compounds formed by oxidative stress.   This capture prevents those compounds from binding to and damaging other cellular components like proteins, lipids, or DNA and impeding normal function of the cell.  

An NIH-funded study found that Hobamine™ supplementation led to positive changes in 15 inflammatory biomarkers associated with immune system balance in both younger and older adults. Hobamine™ works by scavenging pro-inflammatory reactive lipids, helping maintain immune homeostasis, and supporting your immune system's ability to stay in balance even when exposed to oxidative stressors. Hobamine™ has been shown to promote normal cell function in brain cells, blood vessels, and heart, lung, and immune cells from the effects of oxidative stress, which helps to support healthy function. Hobamine™ is an emerging solution for anyone experiencing the signs of premature aging due to oxidative stress.

L-Ergothioneine (as MitoPrime®) NEW higher dose:

Ergothioneine is a unique amino acid, synthesized by bacteria and fungi, with mushrooms being the richest dietary source. Since its discovery over a century ago, ergothioneine’s distinctive properties have fascinated researchers, leading to growing evidence of its powerful cellular protective capabilities. Recent studies suggest that ergothioneine is a full-spectrum cyto-restorative, defending and repairing cells—including critical structures like DNA and mitochondria—against a wide range of endogenous and exogenous stressors. Its high concentration in mitochondria points to a specialized role in shielding mitochondrial DNA from oxidative damage, a key factor in aging and cellular dysfunction.

Oral supplementation of ergothioneine has been shown to significantly raise its levels in plasma and whole blood, ensuring systemic protection. In a pivotal study, cells exposed to oxidative stress and treated with ergothioneine exhibited remarkable telomere lengthening and a reduction in telomere shortening after just eight weeks. Moreover, ergothioneine treatment boosted telomerase activity—the enzyme responsible for maintaining telomere length—which plays a critical role in cellular longevity.

Another groundbreaking study examined the relationship between ergothioneine levels and mortality in a cohort of 3,200 Swedish adults. Among 112 compounds analyzed, ergothioneine showed the strongest association with reduced mortality. Higher blood levels of ergothioneine were linked to a significant decrease in the risk of all-cause mortality, cardiovascular-related deaths, and the development of heart disease. These compelling findings have led to ergothioneine being referred to as the ‘longevity vitamin,’ underscoring its potential as a powerful contributor to healthspan and lifespan.

Spermidine (as Puremidine®) NEW higher dose:

Spermidine is a polyamine compound found naturally in most living organisms and certain foods.  It has been studied for its potential health benefits since the early 1970’s.  Spermidine is believed to have anti-aging properties that can protect against cellular damage and enhance cell function.  Research has shown that it may improve heart health, increase longevity, and support healthy inflammation levels through the body.  Studies have also demonstrated that spermidine can help boost cognitive function and memory by stimulating the release of brain-derived neurotropic factor (BDNF) and increasing the number of synaptic connections in the brain.  Another potential benefit of spermidine is its ability to reduce oxidative stress and improve mitochondrial function.  Spermidine has been shown to help protect our cells from damage of aging, which leads to a host of age-related disease.  Research has shown that when spermidine is supplemented, it can help lengthen telomeres and restore their protective effects.  It also helps improve cell metabolism, which can result in increased energy production and better overall health. 

Sulforaphane Glucosinolate (as Activated BroccoRaphanin®)

Sulforaphane, an isothiocyanate derived from the metabolite glucoraphanin, is a powerful phytonutrient found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. Extensive research has highlighted sulforaphane’s numerous health benefits, particularly its ability to reduce oxidative stress and regulate inflammation, two key factors in chronic disease and aging.

In addition to its therapeutic potential, sulforaphane has been studied for its ability to enhance the body’s natural defense systems. It activates a range of protective enzymes that shield cells and DNA from damage caused by environmental stressors and toxins. This activation promotes the body’s innate detoxification processes, helping to eliminate harmful substances at the cellular level.

A key component in this process is the enzyme myrosinase, which is essential for the conversion of glucoraphanin to sulforaphane. This enzyme, present in cruciferous plants, is released during chewing or chopping, initiating the activation of sulforaphane. In products like Telomere Prime, the inclusion of myrosinase ensures optimal conversion and bioavailability of sulforaphane, maximizing its protective and detoxifying effects.

PQQ (Pyrroloquinoline Quinone) NEW addition:

Pyrroloquinoline quinone (PQQ) is a potent bioactive compound known for its significant role in promoting cellular health, particularly in the context of telomere maintenance, DNA repair, longevity, and mitochondrial function. Research indicates that PQQ may enhance telomerase activity, the enzyme responsible for preserving telomere length, thereby supporting cellular aging and longevity. Additionally, PQQ exhibits strong antioxidant properties that help mitigate oxidative stress, a major contributor to DNA damage, thereby facilitating efficient DNA repair mechanisms. Furthermore, PQQ is crucial for mitochondrial health, as it promotes mitochondrial biogenesis—the formation of new mitochondria—and protects existing ones from oxidative damage, ensuring optimal energy production within cells. Collectively, these actions position PQQ as a valuable compound for enhancing healthspan and combating age-related cellular decline.

AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing astragaloside I, II, IV and ginsenoside Rb1 NEW addition:

AstraGin® is a proprietary, plant-derived compound complex, developed using advanced pharmaceutical extraction and processing technologies. It works by upregulating the mRNA and protein expression of key nutrient transporters in the gut, optimizing the absorption of vital nutrients and plant compounds. Extensive research, including 16 in vitro and 8 in vivo studies published in respected journals such as Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research, and Scientific Reports, highlights AstraGin®'s potent benefits.

Astragalus membranaceus and Panax notoginseng are two revered medicinal plants whose root extracts contain bioactive compounds such as astragaloside I, II, IV, and ginsenoside Rb1, which have shown promise in promoting telomere health and supporting healthy aging. Astragalosides, particularly astragaloside IV, are known to enhance telomerase activity, which helps maintain telomere length and protect against the cellular aging process. This is crucial for preserving chromosomal integrity as cells replicate. Meanwhile, ginsenoside Rb1 from Panax notoginseng exhibits antioxidant properties that mitigate oxidative stress, a major contributor to telomere shortening and age-related degeneration. Together, these compounds not only support the maintenance of telomere length but also contribute to improved cellular function, enhanced immune response, and overall vitality.

Buckwheat Peptides

The protein isolated from buckwheat have been hydrolyzed into a range of peptides.  These peptides showed diverse biological activities in vitro and in vivo.  They include trypsin inhibition, anti-aging, modulating gut microbiota, heart, and immune support.  

Telomere Prime showcases the latest advancements in healthy aging support and features ac-11 Cat’s Claw, 2-hoba, L-ergothioneine, spermidine, sulforaphane with myrosinase and buckwheat peptides.   It is the perfect way to give your cells the boost they need to stay health and support your overall health as you age.  So, if you are looking for a natural way to support your longevity, Telomere Prime is part of your solution.