NMN 1000+

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Introducing a powerful, cutting-edge supplement designed to support and enhance healthy NAD+ levels—vital for energy, cellular repair, and overall vitality. This innovative formula combines NMN (Nicotinamide Mononucleotide), a precursor to NAD+, with TMG(Trimethylglycine), which helps optimize methylation and support detoxification. Added Pterostilbene, a potent antioxidant, helps protect cells from oxidative stress while promoting healthy aging, and Apigenin, a natural flavonoid, further supports cellular health and cognitive function. Together, these ingredients work synergistically to elevate NAD+ levels, boost energy support, improve metabolic function, and promote longevity.

Nicotinamide Mononucleotide: 1,000mg

Key Benefits:

  • Boosts NAD+ Levels: Nicotinamide Mononucleotide is a direct precursor to NAD+, an essential molecule for energy production and cellular repair. By replenishing NAD+, NMN combats age-related declines in mitochondrial function and supports optimal metabolism.
  • Supports Longevity Pathways: Nicotinamide Mononucleotide activates sirtuins, enzymes that regulate DNA repair, inflammation control, and cellular health.
  • Enhances Physical and Cognitive Performance: Higher NAD+ levels improve endurance, recovery, and brain function.

Scientific Evidence:

  • Studies show Nicotinamide Mononucleotide supplementation restores NAD+ levels, improving mitochondrial function and lifespan in animal models【1】
  • Human trials demonstrate Nicotinamide Mononucleotide's ability to enhance blood flow and muscle oxygenation【2】

Trimethylglycine (TMG) (as Betaine Anhydrous): 500mg

Key Benefits:

  • Supports Methylation Processes: TMG acts as a methyl donor, critical for processing homocysteine into methionine. This helps maintain healthy DNA and supports NMN's conversion into NAD+.
  • Protects Cells from Stress: TMG stabilizes proteins and cell membranes under osmotic stress, ensuring cellular integrity.
  • Supports Heart and Liver Health: Helps support homocysteine levels and cardiovascular risk factors.

Scientific Evidence:

  • Research highlights TMG’s role in enhancing cellular methylation and metabolic efficiency【3】【4】
  • TMG improves physical endurance and energy production in athletes【5】

Pterostilbene: 50mg

Key Benefits:

  • Antioxidant Powerhouse: A more bioavailable analog of resveratrol, pterostilbene neutralizes free radicals and protects against oxidative damage.
  • Activates Sirtuins: Supports longevity by enhancing sirtuin activity, which depends on NAD+.
  • Supports Cognitive Function: Protects brain cells from age-related decline, enhancing memory and focus.

Scientific Evidence:

  • Studies suggest pterostilbene is more bioavailable and effective than resveratrol at promoting cellular health【6】【7】.
  • Pterostilbene has anti-inflammatory effects, supporting cardiovascular and brain health【8】.

Apigenin: 50mg

Key Benefits:

  • Inhibits CD38: Apigenin blocks CD38, an enzyme that depletes NAD+ levels, ensuring more NAD+ is available for critical cellular processes.
  • Anti-Inflammatory Properties: Supports chronic inflammation, a key driver of aging and age-related diseases.
  • Protects Against Oxidative Stress: Enhances cellular resilience by reducing oxidative damage to DNA, proteins, and lipids.

Scientific Evidence:

  • Research confirms apigenin’s ability to inhibit CD38 and increase NAD+ availability【9】【10】.
  • Apigenin also shows neuroprotective effects, supporting healthy brain aging【11

The Synergy of Science

By combining these four powerhouse ingredients,  supports NAD+ production through multiple pathways:

  • NMN: Directly replenishes NAD+ levels.
  • TMG: Facilitates Nicotinamide Mononucleotide metabolism via methylation.
  • Pterostilbene: Protects and enhances NAD+ and Sirtuin activity.
  • Apigenin: Reduces NAD+ depletion by inhibiting CD38.

References

  1. Mills, K. F., et al. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism.
  2. Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology.
  3. Craig, S. A. (2004). Betaine in human nutrition. American Journal of Clinical Nutrition.
  4. Zhao, X., et al. (2018). TMG alleviates mitochondrial stress by supporting methylation. Cell Reports.
  5. Hoffman, J. R., et al. (2009). Betaine supplementation and exercise performance. Journal of the International Society of Sports Nutrition.
  6. Remsberg, C. M., et al. (2008). Pharmacokinetics and metabolism of pterostilbene. Life Sciences.
  7. Rimando, A. M., et al. (2005). Pterostilbene as an antioxidant. Journal of Agricultural and Food Chemistry.
  8. McCormack, D., & McFadden, D. (2013). Pterostilbene and cancer. Antioxidants & Redox Signaling.
  9. Chini, C., et al. (2017). CD38 as a regulator of cellular NAD+ homeostasis. Nature Metabolism.
  10. Escande, C., et al. (2013). Apigenin and CD38 inhibition. Journal of Molecular Biology.
  11. Nabavi, S. F., et al. (2015). Neuroprotective effects of apigenin. Current Neurovascular Research.

Additional Key References on  NAD

  • Song, Qin et al. “The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.” Advances in nutrition (Bethesda, Md.) vol. 14,6 (2023): 1416-1435. doi:10.1016/j.advnut.2023.08.008
  • Yi, Lin et al. “The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.” GeroScience vol. 45,1 (2023): 29-43. doi:10.1007/s11357-022-00705-1
  • Soma, Mounica, and Satya Kumar Lalam. “The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions.” Molecular biology reports vol. 49,10 (2022): 9737-9748. doi:10.1007/s11033-022-07459-1
  • Wei, Zisong et al. “Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?.” Current opinion in pharmacology vol. 60 (2021): 291-297. doi:10.1016/j.coph.2021.08.006
  • Rahman, Sajid Ur et al. “Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging.” Aging and disease vol. 15,2 565-583. 1 Apr. 2024, doi:10.14336/AD.2023.0519-1
  • Fukamizu, Yuichiro et al. “Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.” Scientific reports vol. 12,1 14442. 24 Aug. 2022, doi:10.1038/s41598-022-18272-y

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