NMN 1000+

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Reignite Your Cellular Vitality

NMN 1000+ is a precision-formulated supplement designed to support the body’s natural production of NAD+ (Nicotinamide Adenine Dinucleotide) — a coenzyme essential for cellular energy, DNA integrity, and healthy aging.
This advanced blend combines NMN, TMG, Pterostilbene, and Apigenin to deliver multi-pathway support for energy metabolism, cellular resilience, and longevity.

Key Benefits

  • Supports healthy NAD+ levels and mitochondrial energy production*

  • Promotes cellular repair and metabolic efficiency

  • Encourages balanced methylation and detoxification pathways

  • Helps protect cells from oxidative stress and environmental challenges

  • Supports brain performance and overall vitality

NMN (Nicotinamide Mononucleotide) — 1,000 mg

NMN is a direct precursor to NAD+, the molecule that fuels energy production in every cell. By supporting NAD+ biosynthesis, NMN promotes mitochondrial efficiency, cellular renewal, and metabolic performance. It also contributes to healthy sirtuin activity, proteins that help maintain cellular integrity and longevity.

TMG (Trimethylglycine / Betaine Anhydrous) — 500 mg

TMG is an essential methyl donor that plays a vital role in maintaining balanced homocysteine metabolism and supporting NMN’s efficient utilization. It contributes to DNA stability, liver function, and cellular detoxification, while also helping sustain consistent energy metabolism.

Pterostilbene — 50 mg

A naturally occurring polyphenol closely related to resveratrol, Pterostilbene provides potent antioxidant and longevity support. Its superior bioavailability allows it to reach cellular targets effectively, promoting healthy sirtuin activation, metabolic balance, and neuronal protection.

Apigenin — 50 mg

Apigenin is a bioactive flavonoid found in parsley and chamomile that supports cellular health and brain function. It helps maintain NAD+ availability by supporting balanced enzyme activity, while also offering neuroprotective and antioxidant benefits. 

Multi-Pathway Synergy

NMN 1000+ targets multiple biological routes to sustain optimal NAD+ levels and energy metabolism:

  • NMN → Direct NAD+ Precursor*

  • TMG → Supports efficient methylation and NAD+ cycling*

  • Pterostilbene → Promotes antioxidant defense and sirtuin signaling*

  • Apigenin → Helps maintain NAD+ balance and cellular resilience*

Together, these ingredients form a synergistic system that helps the body renew, protect, and energize itself at the cellular level.

References

  1. Mills, K. F., et al. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism.
  2. Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology.
  3. Craig, S. A. (2004). Betaine in human nutrition. American Journal of Clinical Nutrition.
  4. Zhao, X., et al. (2018). TMG alleviates mitochondrial stress by supporting methylation. Cell Reports.
  5. Hoffman, J. R., et al. (2009). Betaine supplementation and exercise performance. Journal of the International Society of Sports Nutrition.
  6. Remsberg, C. M., et al. (2008). Pharmacokinetics and metabolism of pterostilbene. Life Sciences.
  7. Rimando, A. M., et al. (2005). Pterostilbene as an antioxidant. Journal of Agricultural and Food Chemistry.
  8. McCormack, D., & McFadden, D. (2013). Pterostilbene and cancer. Antioxidants & Redox Signaling.
  9. Chini, C., et al. (2017). CD38 as a regulator of cellular NAD+ homeostasis. Nature Metabolism.
  10. Escande, C., et al. (2013). Apigenin and CD38 inhibition. Journal of Molecular Biology.
  11. Nabavi, S. F., et al. (2015). Neuroprotective effects of apigenin. Current Neurovascular Research.

Additional Key References on  NAD

  • Song, Qin et al. “The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.” Advances in nutrition (Bethesda, Md.) vol. 14,6 (2023): 1416-1435. doi:10.1016/j.advnut.2023.08.008
  • Yi, Lin et al. “The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.” GeroScience vol. 45,1 (2023): 29-43. doi:10.1007/s11357-022-00705-1
  • Soma, Mounica, and Satya Kumar Lalam. “The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions.” Molecular biology reports vol. 49,10 (2022): 9737-9748. doi:10.1007/s11033-022-07459-1
  • Wei, Zisong et al. “Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?.” Current opinion in pharmacology vol. 60 (2021): 291-297. doi:10.1016/j.coph.2021.08.006
  • Rahman, Sajid Ur et al. “Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging.” Aging and disease vol. 15,2 565-583. 1 Apr. 2024, doi:10.14336/AD.2023.0519-1
  • Fukamizu, Yuichiro et al. “Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.” Scientific reports vol. 12,1 14442. 24 Aug. 2022, doi:10.1038/s41598-022-18272-y

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