Mitochondria Prime+™

Advanced Mitochondrial Healthspan Support

ATP Production • Redox Balance • Cellular Renewal†

Every hallmark of aging converges on one organelle. Mitochondria Prime+™ was built to support all the ways it declines.*

Mitochondria are not merely energy producers. They are the cellular command centers for metabolic flexibility, redox signaling, apoptosis regulation, and the integration of internal and external stress signals. When mitochondrial function declines — as it does progressively with age — the downstream consequences span every tissue and system: reduced energy output, impaired cognitive clarity, slower muscle recovery, diminished immune resilience, and accelerated cellular aging across the board.

Mitochondria Prime+™ addresses mitochondrial health through three non-redundant pillars — Power, Protect, and Renew — with seven clinically studied ingredients targeting the distinct and interconnected mechanisms that determine how well mitochondria function, how long they survive, and how effectively they are renewed.*

KEY SUPPORTED BENEFITS

Mitochondria Prime+™ is formulated to support:*

• Healthy cellular ATP production and mitochondrial energy efficiency*
• Mitochondrial renewal and mitophagy-related cellular housekeeping*
• Redox balance and endogenous antioxidant defense — Nrf2, glutathione, and beyond*
• Cell membrane stability and mitochondrial resilience against oxidative stress*
• Cognitive clarity, focus, and neuronal energy metabolism*
• Muscle performance, endurance, and post-exercise recovery*
• Healthy fatty acid transport and utilization for cellular energy production*
• Long-term cellular vitality and healthspan signaling*

THE THREE-PILLAR MITOCHONDRIAL HEALTHSPAN SYSTEM

• Power → Acetyl-L-Carnitine + Riboflavin-5'-Phosphate (fatty acid transport, electron transport chain)
• Protect → Algevity® + MitoPrime® + Astaxanthin + Selenium (Nrf2, redox defense, membrane integrity)
• Renew → Naturalin™ Pro ( direct urolithin delivery + ellagic acid precursor)

THE FORMULA — SEVEN INGREDIENTS. THREE BIOLOGICAL PILLARS.

PILLAR ONE: POWER

Supporting Cellular Energy Production and Mitochondrial Efficiency

Acetyl-L-Carnitine HCl (ALCAR)

Dose: 750 mg Role: Fatty Acid Transport & Neuronal Energy Metabolism

Acetyl-L-Carnitine is the acetylated form of L-Carnitine — uniquely positioned to cross the blood-brain barrier and support neuronal energy metabolism alongside its primary role in mitochondrial fatty acid transport.*

ALCAR's central function in mitochondrial bioenergetics is the transport of long-chain fatty acids across the inner mitochondrial membrane and into the mitochondrial matrix, where they undergo beta-oxidation to generate acetyl-CoA for ATP production.* Without sufficient carnitine, fatty acid oxidation slows and mitochondrial energy output declines — a process that accelerates with age as endogenous carnitine biosynthesis decreases.*

The acetyl group on ALCAR provides a second mechanism: acetylcholine precursor support in neuronal tissue, contributing to neurotransmitter synthesis and supporting the cognitive energy metabolism that underpins mental clarity, focus, and neuroprotection.*

ALCAR's clinical evidence across aging adults supports its role in maintaining cognitive function, reducing mental fatigue, and supporting neuronal energy metabolism — making it the essential bioenergetics foundation of Mitochondria Prime+™.*

Riboflavin-5'-Phosphate Sodium (Active B2)

Dose: 50 mg Role: Electron Transport Chain Cofactor & Mitochondrial Energy Pathway Support

Riboflavin (Vitamin B2) is an essential mitochondrial cofactor — specifically as the precursor to FAD (flavin adenine dinucleotide) and FMN (flavin mononucleotide), the two coenzymes that serve as critical electron carriers in the mitochondrial electron transport chain.* Without adequate FAD and FMN, electron flow through Complex I and Complex II stalls and ATP production drops.*

Mitochondria Prime+™ uses riboflavin-5'-phosphate — the bioactive, phosphorylated form of B2 that is already in the activated cofactor state, bypassing the conversion step required for standard riboflavin. This is particularly meaningful for patients with riboflavin kinase enzyme variations that limit conventional riboflavin activation, and for ensuring consistent electron transport chain support regardless of individual metabolic variation.*

At 50 mg — significantly above the standard RDA — Mitochondria Prime+™ delivers riboflavin at a dose designed to meaningfully support electron transport chain function in a clinical context, not merely prevent deficiency.*

PILLAR TWO: PROTECT

Redox Defense, Nrf2 Pathway Support & Membrane Integrity

Algevity® (Ulva lactuca Supercritical CO₂ Extract)

Dose: 300 mg Role: Nrf2-Mediated Cellular Defense & Upstream Redox Protection Healthgevity Exclusive

Algevity® is a supercritical CO₂ extract of Ulva lactuca — a green marine algae selected from a screening of 30 marine algae species as the most potent activator of the Nrf2-ARE pathway identified in that analysis.*

The Nrf2 (Nuclear factor erythroid 2-related factor 2) pathway is the body's master switch for endogenous antioxidant defense — when activated, Nrf2 translocates to the nucleus, binds the Antioxidant Response Element (ARE), and upregulates over 200 cytoprotective genes, including:*

• NQO1 (NAD(P)H:quinone oxidoreductase 1)*
• Heme oxygenase-1 (HO-1)*
• Thioredoxin reductase 1*
• Glutamate-cysteine ligase (both subunits) — the rate-limiting enzyme in glutathione synthesis*
• The cystine/glutamate exchange transporter*

Published research in Free Radical Biology and Medicine identified three monounsaturated fatty acid (MUFA) derivatives from Ulva lactuca — including a novel keto-type C18 fatty acid — as the active Nrf2 activators, showing ARE-activating effects in human neuroblastoma cells and significant induction of Nrf2-driven cytoprotective genes in vivo.*

Ulva lactuca also provides sulfated polysaccharides (ulvans) that support healthy inflammatory signaling, mitochondrial function support, and gut microbiome balance.*

Supercritical CO₂ extraction preserves thermolabile bioactive compounds that would be destroyed by conventional solvent or heat-based extraction — delivering the full bioactive profile of Ulva lactuca in a concentrated, clean extract.*

Algevity® is a Healthgevity Exclusive — this ingredient at this extraction standard is not available in retail or general practitioner-channel supplements.*

MitoPrime® L-Ergothioneine

Dose: 25 mg Role: "The Longevity Vitamin" — Selective Cellular Antioxidant Accumulation & Mitochondrial Resilience 

L-Ergothioneine is a unique dietary amino acid — a sulfur-containing thiohistidine betaine found in the highest concentrations in mushrooms — that three major scientific reviews published in 2022, 2023, and 2024 have elevated from "interesting antioxidant" to what many researchers now characterize as a "longevity vitamin" essential for healthy aging.*

What makes L-Ergothioneine biologically distinct from conventional antioxidants:

Dedicated transporter-mediated tissue accumulation: L-Ergothioneine is actively transported into cells and tissues via a dedicated transporter protein (OCTN1/SLC22A4) — one found in tissues with the highest metabolic activity and oxidative demand, including red blood cells, liver, kidney, brain, and eyes. Rather than being uniformly distributed or rapidly excreted, ergothioneine accumulates precisely where antioxidant protection is needed most.*

Longest half-life of known oral antioxidants: Unlike most dietary antioxidants that are rapidly metabolized and excreted, ergothioneine is retained by the body with an exceptionally long half-life — functioning as a standing reserve of antioxidant protection rather than a time-limited acute effect.*

Mitochondrial uptake: Research demonstrates that ergothioneine is taken up and accumulated by mitochondria — with uptake occurring even in isolated mitochondria independent of the cell-surface transporter — positioning it directly at the site of highest oxidative stress in the cell.*

Declining levels with age and cognitive implications: Ergothioneine plasma levels decline measurably with age. Emerging research associates lower ergothioneine levels with reduced cognitive reserve and impaired mitochondrial function. Higher dietary ergothioneine intake has been associated with longer healthspan in population-level analyses.*

MitoPrime® is a pharmaceutical-grade, fermentation-derived L-Ergothioneine from NNB Nutrition — delivering the pure L-isomer at a dose that mirrors the research literature supporting its longevity and mitochondrial protection applications.*

The 2024 review published in Protein & Cell, alongside 2022 and 2023 reviews in peer-reviewed journals, collectively support ergothioneine's role in supporting mitochondrial function, cellular redox homeostasis, anti-inflammatory signaling, and healthy aging across multiple tissue systems.*

Astaxanthin

Dose: 12 mg Role: Membrane-Integrated Antioxidant & Mitochondrial Membrane Resilience

Astaxanthin is a xanthophyll carotenoid that occupies a unique structural position in cell biology: its polar end groups span both the intracellular and extracellular faces of lipid bilayer membranes simultaneously — providing antioxidant protection across the entire membrane thickness, not just at the surface.*

This membrane-spanning architecture makes astaxanthin unusually effective at protecting cell membranes and mitochondrial membranes from lipid peroxidation — the chain-reaction oxidative damage to membrane fatty acids that impairs mitochondrial function and cellular integrity.*

Astaxanthin is documented to be 550 times more potent as a singlet oxygen quencher than Vitamin E and 6,000 times more potent than Vitamin C — though these comparisons reflect specific mechanisms rather than overall antioxidant equivalence. More clinically relevant: astaxanthin crosses the blood-brain barrier and the blood-retinal barrier, providing antioxidant protection in neuronal and retinal tissue where oxidative stress is particularly consequential.*

The 12 mg dose in Mitochondria Prime+™ is in the upper range of doses used in human clinical trials demonstrating benefits for oxidative stress markers, cognitive performance, and exercise recovery — ensuring meaningful mitochondrial and cellular membrane protection at a clinically relevant level.*

Selenium as L-Selenomethionine

Dose: 100 mcg Role: Glutathione Peroxidase & Antioxidant Enzyme System Support

Selenium is the essential mineral cofactor for glutathione peroxidase (GPx) — one of the primary enzymatic antioxidant defense systems that neutralizes hydrogen peroxide and lipid hydroperoxides before they can damage cellular components and mitochondrial membranes.*

Without adequate selenium, GPx activity declines and the cellular redox burden increases — a compounding problem in the context of aging-related oxidative stress. L-Selenomethionine is the most bioavailable organic form of selenium, with significantly higher absorption and tissue retention compared to inorganic selenium sources (selenate or selenite).*

Selenium also supports the deiodinase enzymes that activate thyroid hormone — adding a metabolic and energy regulation dimension to its antioxidant role.*

At 100 mcg, Mitochondria Prime+™ delivers selenium at the upper end of the optimal intake range — supporting glutathione peroxidase activity without approaching the upper tolerable intake level.*

PILLAR THREE: RENEW

Precision Cellular Renewal & Healthy Aging Support

Naturalin™ Pro

Dose: 700 mg total (Naturalin®  + Urolithin A + Urolithin B) 

Naturalin™ Pro is an exclusive three-component cellular renewal complex that combines direct Urolithin A, direct Urolithin B, and highly bioavailable Naturalin® in a single advanced formulation. Unlike conventional urolithin supplements that rely primarily on gut microbiome conversion, Naturalin™ Pro delivers active urolithins directly while also providing a patented precursor to support continued urolithin production. This comprehensive approach helps overcome one of the biggest limitations of traditional urolithin supplementation—individual variability in gut microbiome conversion.

Why Most Urolithin Supplements Fall Short

Most urolithin products depend entirely on the gut microbiome to convert dietary ellagic acid or pomegranate-derived compounds into active urolithins. Research suggests that only a portion of the population efficiently produces meaningful levels of Urolithin A, leaving many individuals with limited exposure despite supplementation.*

Naturalin™ Pro was developed to overcome this challenge by combining:

• Direct Urolithin A for immediate cellular support*
• Direct Urolithin B for complementary healthy aging support*
• Naturalin®, a patented, highly bioavailable ellagic acid precursor designed to support continued microbiome-derived urolithin production*

The result is a more comprehensive approach than products relying on a single ingredient alone.*

Why Three Components Matter

Urolithin A

The most extensively researched member of the urolithin family, Urolithin A has become one of the leading ingredients in longevity science for its ability to support healthy cellular renewal pathways, mitochondrial quality, muscle health, and healthy aging.*

Urolithin B

Urolithin B is a distinct urolithin metabolite that complements Urolithin A through different biological pathways. Emerging research suggests it may help support healthy skeletal muscle physiology and healthy muscle maintenance, making it an important companion to Urolithin A within a comprehensive healthy aging strategy.*

Naturalin®

Naturalin® is Halo Life Science's patented choline salt of ellagic acid, engineered to be over 1,000 times more soluble than conventional ellagic acid. This enhanced solubility supports superior bioavailability while serving as a highly efficient precursor for continued microbiome-mediated urolithin production.*

Beyond its role as a precursor, Naturalin® also supports healthy glucose metabolism, antioxidant defenses, and overall cellular health through ellagic acid's naturally occurring bioactivities.*

Naturalin™ Pro is a Healthgevity Exclusive formulation — this three-component urolithin + precursor system is not available in retail or general practitioner-channel supplements.*

WHY SEVEN INGREDIENTS AT THESE DOSES

Most mitochondrial supplements rely on CoQ10, alpha lipoic acid, or NAD+ precursors — addressing one or two pathways at the surface level. Mitochondria Prime+™ was built differently.

ALCAR and Riboflavin-5'-Phosphate support the energy production infrastructure — the electron transport chain and fatty acid oxidation machinery that generates ATP.*

Algevity® activates the Nrf2 master switch — upregulating the body's own endogenous antioxidant defense network across over 200 cytoprotective genes, rather than simply supplementing individual antioxidants.*

MitoPrime® accumulates in the mitochondria and tissues that need it most — providing standing antioxidant protection with the longest half-life of any known oral antioxidant.*

Astaxanthin integrates into mitochondrial membranes — protecting the lipid bilayer structures that determine membrane potential and electron transport chain function.*

Selenium provides the essential cofactor for glutathione peroxidase — the enzymatic defense system that neutralizes peroxides before they damage mitochondrial components.*

This is a systems-level formula. Power, protect, and renew — simultaneously.*