SLEEPgevity™

Restorative sleep is not just about falling asleep. It is about what happens while you are.*

Deep sleep and REM sleep are when the brain consolidates memory, the body undergoes tissue repair, the immune system resets, and the glymphatic system clears metabolic waste from the brain. These are not passive processes — they are the most biologically active phases of the 24-hour cycle. Disrupting them does not just leave you tired. It accelerates biological aging, impairs cognitive performance, compromises immune resilience, and undermines the efficacy of every other longevity intervention your patients are investing in.*

SLEEPgevity™ was designed to support the full architecture of restorative sleep — from the stress and wakefulness signaling that determines sleep onset, through the deep and REM stages that determine sleep quality, to the neurological and hormonal environment that supports morning clarity and next-day performance.*

Six clinically studied ingredients. One melatonin-free formula. Non-sedating, non-habit forming, and specifically designed for practitioners who understand that sleep is not a passive state — it is the foundation everything else is built on.*

KEY SUPPORTED BENEFITS

SLEEPgevity™ is formulated to support:*

• Healthy sleep onset — falling asleep faster through orexin and cortisol pathway support*
• Healthy deep sleep (non-REM) and REM sleep architecture and duration*
• Melatonin synthesis through the tryptophan-serotonin-melatonin pathway*
• HPA-axis cortisol balance for smoother evening wind-down*
• GABAergic calming and balanced neurotransmitter tone before sleep*
• Gut-brain axis GABA production through LP815™ probiotic*
• Heart rate variability and parasympathetic nervous system activation during sleep*
• Morning refreshment, mental clarity, and cognitive readiness upon waking*

THE SIX-PATHWAY SLEEP ARCHITECTURE SYSTEM

• Orexin & Cortisol Modulation → PeptiSleep™ (AI-discovered · Nuritas · world-first sleep peptide)
•  Circadian Melatonin Pathway → Tryptophan (5-HTP → serotonin → melatonin precursor cascade)
•  HPA-Axis Cortisol Balance → Holixer™ Holy Basil (−66% hair cortisol · 2 RCTs · 170 subjects)
• Serotonergic Sleep Onset → affron® (8 human trials · 41% mood improvement · sleep quality support)
• Gut-Brain GABA Production → LP815™ L. plantarum (next-generation GABA-producing probiotic)
•  Alpha-Wave Calming → L-TeaActive® L-Theanine (non-sedating · alpha brainwave activity)

THE FORMULA

PeptiSleep™

Role: Orexin Pathway Modulation, Cortisol Support & Circadian Sleep Architecture Developed with Nuritas · AI-Discovered · World's First Sleep-Specific Bioactive Peptide · Melatonin-Free

PeptiSleep™ is the most important clinical differentiator in the SLEEPgevity™ formula — and one of the most novel ingredients in the entire Healthgevity catalog. It is the world's first bioactive peptide developed specifically for sleep support, identified through Nuritas's Magnifier™ AI platform from a food protein matrix and validated for its sleep-regulatory activity.*

The story of why PeptiSleep™ matters begins with understanding why conventional sleep supplements fail. Most approach sleep through a single pathway — typically melatonin for circadian timing or GABA for calming. Neither addresses the wakefulness signaling that is the primary neurobiological obstacle to healthy sleep onset in stressed, high-demand individuals.

PeptiSleep™ works through two complementary sleep-regulatory pathways:*

Orexin (Hypocretin) Pathway Support: Orexin is the neuropeptide responsible for maintaining wakefulness and arousal — it is the biological system that keeps the brain in an alert state. Elevated or dysregulated orexin signaling is one of the most significant barriers to sleep onset, particularly in individuals under chronic stress or cognitive overload. PeptiSleep™ supports healthy downregulation of orexin pathway activity — supporting the neurological transition from wakefulness to sleep onset.* This mechanism is distinct from and complementary to GABAergic calming — addressing the wakefulness signal rather than simply adding an inhibitory counterbalance.*

Cortisol Modulation: Elevated evening cortisol is a primary driver of sleep onset difficulty and fragmented sleep architecture. PeptiSleep™ supports healthy cortisol levels during the evening transition period — reducing the stress-mediated hyperarousal that prevents the brain from entering the deeper stages of sleep.*

By addressing both the wakefulness signal (orexin) and the stress signal (cortisol) simultaneously, PeptiSleep™ facilitates a smooth, physiologically aligned transition into sleep and supports the maintenance of healthy sleep architecture throughout the night.*

PeptiSleep™ is melatonin-free — it supports the biological conditions for healthy sleep rather than forcing the circadian signal. This makes it appropriate for long-term daily use without circadian rhythm disruption or next-day grogginess.*

Powered by Nuritas. [Learn more about our Nuritas partnership →]

Tryptophan (L-Tryptophan)

Role: Serotonin-Melatonin Precursor Pathway & Circadian Rhythm Support

Tryptophan is the essential amino acid that initiates the body's own melatonin synthesis pathway — providing the raw material for the full neurochemical cascade that governs sleep-wake timing.*

The pathway: dietary tryptophan → 5-HTP (5-hydroxytryptophan) → serotonin → N-acetylserotonin → melatonin.

By supporting this natural biosynthetic route, tryptophan complements PeptiSleep™'s orexin and cortisol modulation with support for the circadian melatonin signal that aligns sleep timing with the natural light-dark cycle.* This is the critical distinction from direct melatonin supplementation: supporting the body's own melatonin synthesis rather than supplying exogenous melatonin preserves the natural amplitude and rhythm of the melatonin peak — avoiding the circadian disruption and receptor desensitization associated with long-term exogenous melatonin use.*

Tryptophan also supports serotonin production as an intermediate step — contributing to daytime mood stability, emotional regulation, and the neurochemical foundation for healthy evening wind-down.*

DHH-B (Dihydrohonokiol-B from Magnolia officinalis Bark Extract)

Role: GABAergic Calming, Fast-Acting Sleep Onset Support & Neuroprotection

DHH-B is a specialized, highly purified derivative of honokiol — the primary bioactive compound in Magnolia bark — with enhanced potency and selectivity compared to standard honokiol extracts.*

DHH-B's primary mechanism is modulation of GABA-A and GABA-C receptor-gated chloride channel activity — supporting the inhibitory neurotransmitter signaling that calms neuronal excitability and promotes the relaxed neurological state associated with sleep onset. Unlike parent honokiol, which requires repeated administration to accumulate the active metabolite responsible for its calming effects, DHH-B acts directly and rapidly — making it particularly relevant for sleep onset support.

Holixer™ (Ocimum tenuiflorum / Holy Basil Extract, standardized to ≥5% Ocimum Bioactive Complex)

Role: HPA-Axis Cortisol Balance, Evening Stress Modulation & Sleep Quality Support 

Holixer™ is the HPA-axis regulatory layer of SLEEPgevity™ — addressing the cortisol dysregulation that is one of the most common sleep disruptors in stressed adult populations. It is the same ingredient featured in Serenity for daytime stress resilience, carrying the same clinical evidence base into the sleep context.*

The primary 8-week double-blind, randomized, placebo-controlled trial (n=100, Frontiers in Nutrition, 2022) demonstrated significantly lower salivary cortisol (p=0.001) and salivary amylase in response to acute stress, significantly lower hair cortisol at 8 weeks (p=0.025) — a chronic, objective measure of cumulative cortisol output — and significantly improved Athens Insomnia Scale scores (p=0.025) versus placebo.*

The expanded 2025 clinical program across 170 subjects showed 37% reduction in stress scores and 66% reduction in hair cortisol within 4 weeks, with significant improvements in insomnia symptoms, sleep efficiency, fewer nighttime awakenings, more restorative non-REM sleep, and improved next-day cognitive performance.*

Holixer™'s sleep benefits operate through the HPA-axis — reducing the cortisol that disrupts sleep architecture when elevated during evening hours, supporting the cortisol awakening response (CAR) normal rhythm, and creating the neuroendocrine environment in which deeper sleep stages can occur.*

affron® (Crocus sativus Stigma Extract, standardized to >3.5% Lepticrosalides®)

Dose: 28 mg Role: Serotonergic Support, Pre-Sleep Anxiety Balance & Sleep Quality 

affron® is the most clinically studied saffron extract globally — with eight published human clinical trials supporting its role in mood, stress resilience, and sleep quality.

In the context of SLEEPgevity™, affron® contributes two complementary mechanisms:

Serotonergic and melatonin support: crocin and crocetin support serotonergic neurotransmission, while safranal has been shown to support healthy melatonin production — connecting the mood, stress, and sleep dimensions through a single ingredient.*

Pre-sleep anxiety and mental overactivity: affron® modulates the psychological arousal — racing thoughts, tension, mental overactivity — that prevents sleep onset independently of cortisol levels.* This complements PeptiSleep™'s orexin/cortisol approach with a neurochemical mood dimension.*

Clinical Evidence — affron® for sleep:*

• Randomized, double-blind, placebo-controlled study: participants taking 28 mg/day affron® for 4 weeks reported 41% improvement in mood alongside significant reduction in occasional stress, frustration, and tension*
• affron® has been shown to support overall sleep quality, reduce nighttime awakenings, and support smoother transition into deeper sleep*
• Consistent evidence across 8 human trials at the 28 mg dose used in SLEEPgevity™*
• Non-sedating and non-habit forming — supports sleep quality through neurochemical balance rather than sedation*

LP815™ (Lactiplantibacillus plantarum / GABA-Producing Probiotic)

Role: Gut-Brain Axis GABA Production & Sustained Calming Throughout Night

LP815™ is the gut-brain axis layer of SLEEPgevity™ — producing GABA endogenously through the enteric nervous system and supporting it via the vagal nerve pathway to the brain for a sustained calming effect throughout the night.*

Selected through computational modeling and high-throughput screening for superior GABA production capacity, LP815™ produces GABA consistently in the gastrointestinal environment — providing a more sustained and physiologically natural GABA availability compared to direct GABA supplementation, which produces a transient effect.* This sustained production is particularly relevant for sleep maintenance — supporting continuous GABA signaling throughout the night rather than only at sleep onset.*

LP815™ also supports microbiome balance and gut barrier integrity — maintaining the gut health that underpins the gut-brain communication pathway its GABA production relies on.*

L-TeaActive® L-Theanine

Role: Alpha-Wave Calming, Non-Sedating Relaxation & Synergistic Sleep Quality 

L-TeaActive® L-Theanine completes SLEEPgevity™'s sleep architecture support by promoting alpha brain-wave activity — the neurological state associated with relaxed alertness that bridges the wakefulness-to-sleep transition.*

L-Theanine works through three complementary mechanisms in the sleep context:*

Alpha-wave induction: EEG studies confirm measurable alpha brain-wave activity within 30–45 minutes at therapeutic doses — supporting the calm, receptive neurological state that precedes healthy sleep onset.*

Neurotransmitter balance: L-Theanine supports GABA, serotonin, and dopamine activity — working synergistically with LP815™'s gut-produced GABA, affron®'s serotonergic support, and DHH-B's direct GABAergic receptor modulation.*

Glutamate modulation: L-Theanine partially inhibits excitatory glutamate receptor binding — reducing the neuronal hyperexcitability that contributes to racing thoughts and delayed sleep onset.*

Non-sedating throughout: unlike sedating sleep aids, L-Theanine promotes relaxation without impairing motor function, cognitive clarity, or next-day alertness. It is effective as a sleep onset support ingredient precisely because it does not sedate — it creates the conditions for natural sleep rather than forcing it.*

WHY MELATONIN-FREE MATTERS

SLEEPgevity™ does not contain melatonin — and that is a deliberate clinical decision.

Exogenous melatonin is most evidence-supported for circadian phase shifting (jet lag, shift work) rather than improving sleep quality in individuals with normal circadian timing.* At the doses common in commercial supplements (often 5–10 mg, far above physiological levels), exogenous melatonin can suppress the body's own melatonin production over time and disrupt the natural melatonin rhythm that governs circadian biology.*

SLEEPgevity™ supports the body's own melatonin biosynthesis through the tryptophan-serotonin-melatonin pathway — preserving the natural amplitude and timing of the melatonin peak while addressing the stress, wakefulness, and neurochemical factors that are the primary obstacles to restorative sleep in most patients.*