Resolve + References

General Inflammaging:

  • Ferrucci, Luigi, and Elisa Fabbri. “Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty.” Nature reviews. Cardiology vol. 15,9 (2018): 505-522. doi:10.1038/s41569-018-0064-2
  • Fulop, T et al. “Immunology of Aging: the Birth of Inflammaging.” Clinical reviews in allergy & immunology vol. 64,2 (2023): 109-122. doi:10.1007/s12016-021-08899-6
  • Xia, Shijin et al. “An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment.” Journal of immunology research vol. 2016 (2016): 8426874. doi:10.1155/2016/8426874
  • Calder, Philip C et al. “Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition.” Ageing research reviews vol. 40 (2017): 95-119. doi:10.1016/j.arr.2017.09.001
  • Li, X., Li, C., Zhang, W. et al. Inflammation and aging: signaling pathways and intervention therapies. Sig Transduct Target Ther 8, 239 (2023).
  • Teissier, Thibault et al. “Interconnections between Inflammageing and Immunosenescence during Ageing.” Cells vol. 11,3 359. 21 Jan. 2022, doi:10.3390/cells11030359


  • Benameur, Tarek et al. “Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain.” Molecules (Basel, Switzerland) vol. 26,16 4794. 7 Aug. 2021, doi:10.3390/molecules26164794
  • He, Yan et al. “Curcumin, inflammation, and chronic diseases: how are they linked?.” Molecules (Basel, Switzerland) vol. 20,5 9183-213. 20 May. 2015, doi:10.3390/molecules20059183
  • Uddin, Shaikh Jamal et al. “Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data.” Current drug targets vol. 22,6 (2021): 656-671. doi:10.2174/1389450121666200925150022
  • Zia, Aliabbas et al. “The role of curcumin in aging and senescence: Molecular mechanisms.” Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 134 (2021): 111119. doi:10.1016/j.biopha.2020.111119


  • Lai, Ching-Shu et al. “The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin.” Biomolecules vol. 10,6 831. 29 May. 2020, doi:10.3390/biom10060831
  • Pandey A, Chaturvedi M, Mishra S, Kumar P, Somvanshi P, Chaturvedi R. Reductive metabolites of curcumin and their therapeutic effects. Heliyon. 2020 Nov 12;6(11):e05469. doi: 10.1016/j.heliyon.2020.e05469. PMID: 33241148; PMCID: PMC7674297.


  • Cui, Zhifu et al. “Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism.” Frontiers in immunology vol. 13 943321. 22 Jul. 2022, doi:10.3389/fimmu.2022.943321
  • Deepika, and Pawan Kumar Maurya. “Health Benefits of Quercetin in Age-Related Diseases.” Molecules (Basel, Switzerland) vol. 27,8 2498. 13 Apr. 2022, doi:10.3390/molecules27082498
  • Mlcek, Jiri et al. “Quercetin and Its Anti-Allergic Immune Response.” Molecules (Basel, Switzerland)vol. 21,5 623. 12 May. 2016, doi:10.3390/molecules21050623
  • Immunity.” Nutrients vol. 8,3 167. 15 Mar. 2016, doi:10.3390/nu8030167
  • Shen, Pan et al. “Potential Implications of Quercetin in Autoimmune Diseases.” Frontiers in immunology vol. 12 689044. 23 Jun. 2021, doi:10.3389/fimmu.2021.689044
  • Di Petrillo, Amalia et al. “Quercetin and its derivates as antiviral potentials: A comprehensive review.” Phytotherapy research : PTR vol. 36,1 (2022): 266-278. doi:10.1002/ptr.7309


  • Ragab, E.A., Abd El-Wahab, M.F., Doghish, A.S. et al. The journey of Boswellic acids from synthesis to pharmacological activities. Naunyn-Schmiedeberg's Arch Pharmacol (2023).
  • Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian J Pharm Sci. 2011 May;73(3):255-61. doi: 10.4103/0250-474X.93507. PMID: 22457547; PMCID: PMC3309643.
  • Hüsch, Jan et al. “Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.” Fitoterapia vol. 84 (2013): 89-98. doi:10.1016/j.fitote.2012.10.002
  • Gomaa, Adel A et al. “Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly.” Inflammopharmacology vol. 29,4 (2021): 1033-1048. doi:10.1007/s10787-021-00841-8

Perilla frutescens:

  • Adam, Gigi et al. “Applications of Perilla frutescens Extracts in Clinical Practice.” Antioxidants (Basel, Switzerland) vol. 12,3 727. 16 Mar. 2023, doi:10.3390/antiox12030727
  • Dhyani A, Chopra R, Garg M. A Review on Nutritional Value, Functional Properties and Pharmacological Application of Perilla (Perilla Frutescens L.). Biomed Pharmacol J 2019;12(2).
  • Hou, Tianyu et al. “Perilla frutescens: A Rich Source of Pharmacological Active Compounds.” Molecules (Basel, Switzerland)vol. 27,11 3578. 2 Jun. 2022, doi:10.3390/molecules27113578

Acmella oleracea:

  • Rondanelli, Mariangela et al. “Acmella oleracea for pain management.” Fitoterapia vol. 140 (2020): 104419. doi:10.1016/j.fitote.2019.104419
  • Dallazen, Jorge Luiz et al. “Pharmacological potential of alkylamides from Acmella oleracea flowers and synthetic isobutylalkyl amide to treat inflammatory pain.” Inflammopharmacology vol. 28,1 (2020): 175-186. doi:10.1007/s10787-019-00601-9
  • Abdul Rahim, Rohanizah et al. “Potential Antioxidant and Anti-Inflammatory Effects of Spilanthes acmella and Its Health Beneficial Effects: A Review.” International journal of environmental research and public health vol. 18,7 3532. 29 Mar. 2021, doi:10.3390/ijerph18073532
  • Spinozzi, Eleonora et al. “A Review of the Chemistry and Biological Activities of Acmella oleracea ("jambù", Asteraceae), with a View to the Development of Bioinsecticides and Acaricides.” Plants (Basel, Switzerland) vol. 11,20 2721. 14 Oct. 2022, doi:10.3390/plants11202721
  • Konrath, Eduardo Luis et al. “Acmella oleraceaIs a Medicinal Plant That Decreases Chymase Activity, Oxidative Stress, and Inflammation: Possible Role in the Adjuvant Treatment of COVID-19.” Journal of medicinal food vol. 24,11 (2021): 1243-1244. doi:10.1089/jmf.2021.0055