Hergevity™ Balance

Women's hormonal health is not driven by a single hormone. HERgevity™ Balance was not built around a single solution.*

Estrogen receptor signaling, gut-mediated hormone metabolism, HPA-axis stress response, neurotransmitter balance, and cellular nutrient delivery are separate but deeply interconnected systems. A formula that addresses only one — a phytoestrogen that targets receptor signaling without supporting gut clearance, or a mood botanical without the absorption infrastructure to make it effective — leaves the larger picture unaddressed.

HERgevity™ Balance was designed as a systems-level women's hormonal health formula — supporting the full regulatory network that governs how hormones are produced, metabolized, signaled, and cleared throughout the female lifespan. Rather than forcing hormonal outcomes, it supports the biological systems that allow hormonal balance to emerge naturally.*

KEY SUPPORTED BENEFITS

HERgevity™ Balance is formulated to support:*

• Healthy estrogen receptor-β signaling and hormonal adaptation across life stages*
• Gut barrier integrity and microbiome-mediated estrogen metabolism and clearance*
• Healthy HPA-axis regulation and cortisol rhythm balance*
• Emotional resilience, mood stability, and serotonergic signaling*
• Healthy perimenopausal and menopausal transitions, including vasomotor comfort*
• Healthy LH, FSH, AMH, and estradiol signaling balance*
• Nutrient absorption and cellular bioavailability of active compounds*
• Menstrual comfort and cycle regularity support*

THE SYSTEMS ARCHITECTURE

How HERgevity™ Balance Works

Most women's hormonal formulas address one or two pathways — phytoestrogens for receptor support, or adaptogens for stress. HERgevity™ Balance addresses five simultaneously:

• Endocrine Adaptation → Xeya™ Modern Shatavari (hormonal signaling across life stages)
• Selective Estrogen Receptor-β Support → MENOFELIS® (non-hormonal ER-β activation)
• Neuroendocrine & Mood Resilience → affron® (serotonergic and HPA-axis support)
• Gut–Hormone Axis Integrity → PoZibio® (gut barrier and microbiome-hormone communication)
•  Cellular Delivery Foundation → Ioniplex® + AstraGin® (absorption and mineral support)

THE SIX-INGREDIENT FORMULA

Xeya™ Modern Shatavari (Asparagus racemosus, standardized to 15% shatavarins)

Dose: 100 mg Role: Endocrine Adaptation Across the Female Lifespan 

Xeya™ Modern Shatavari is the most advanced standardized Shatavari extract available — standardized to a market-leading 15% shatavarins, enabling clinically effective hormonal support at a low daily dose of just 50–100 mg. For context, conventional Shatavari extracts typically contain 2–5% shatavarins and require 500–2,000 mg doses to approach comparable activity — making Xeya™ approximately twice as potent at one-fifth the dose.*

Shatavari (Asparagus racemosus) is the "Queen of Ayurvedic Medicine" — used for over 3,500 years to support women's hormonal vitality, reproductive health, and stress resilience. Xeya™ translates this centuries-long tradition into a precision ingredient with two modern human clinical trials.

What distinguishes Xeya™ from other Shatavari extracts is its bidirectional endocrine adaptive mechanism — supporting hormonal signaling whether estrogen activity is elevated, declining, or fluctuating. Rather than pushing hormones in a single direction, it helps the endocrine system respond appropriately to change.*

Clinical Evidence — Two Human Clinical Trials:*

Study 1 — Perimenopausal Women (120-day double-blind, randomized, placebo-controlled trial, n=75, published in Functional Foods in Health and Disease, 2025):*

• 77.3% improvement in somatic symptoms including hot flushes, fatigue, and sleep disturbances versus placebo*
• 74.5% improvement in psychological symptoms including mood swings, anxiety, and brain fog (Menopause Rating Scale)*
• Menopause Rating Scale total score reduced by 51.4% (50 mg) and 72.9% (100 mg) versus 22.8% in placebo*
• Hot Flash Weekly Weighted Score dropped by 27.6–39.8% versus a 7.7% increase in placebo*
• Dose-dependent modulation demonstrated across four hormones: FSH, LH, AMH, and 17β-estradiol*
• Skin and hair quality also improved*

Study 2 — Women with PCOS (84-day randomized, double-blind, placebo-controlled trial, n=60, published in Food & Nutrition Research, 2025):*

• 33.9% reduction in total testosterone*
• 31.8% increase in sex hormone-binding globulin (SHBG)*
• 18.6% improvement in LH:FSH ratio*
• Improved ovarian morphology and menstrual regularity*
• Improved metabolic parameters*

Xeya™ is effective across reproductive years, perimenopausal transition, and menopausal support — making it relevant for women from first menses through post-menopause.*

MENOFELIS® (Rheum rhaponticum Root Extract)

Dose: 4 mg (standardized for rhaponticin and desoxyrhaponticin) Role: Selective Estrogen Receptor-β Support — Non-Hormonal

MENOFELIS® — one of the most extensively clinically studied non-hormonal botanical ingredients for menopausal support, with over 155 million daily doses administered in post-marketing surveillance across Germany, the United States, and Canada without significant adverse events.*

Its clinical uniqueness lies in selective activation of estrogen receptor-β (ER-β) — the receptor subtype primarily associated with thermoregulation, mood stability, vascular health, bone integrity, and urogenital tissue health — while showing minimal activity at estrogen receptor-α. Laboratory studies show MENOFELIS® exerts ER-β activation 13.5-fold greater than its ER-α effects — a selectivity that supports the beneficial aspects of estrogen signaling without stimulating estrogen-sensitive tissues.*

This selective mechanism is what makes MENOFELIS® fundamentally different from phytoestrogens that activate both receptor subtypes — and what supports its safety profile in long-term use.*

Clinical Evidence — Multiple Human Trials:*

• 12-week multicenter randomized, placebo-controlled trial (n=112): significant reduction in Menopause Rating Scale total score, hot flush frequency and severity, anxiety, and depression versus placebo*
• 6-month open observational study (n=252): significant MRS score improvements*
• 48-week and 96-week long-term studies: no endometrial hyperplasia detected; no adverse events related to MENOFELIS®intake*
• Post-marketing surveillance across ~155 million daily doses: excellent tolerability and safety profile*
• Updated S3 German clinical guideline on peri- and postmenopause includes MENOFELIS® for menopausal symptoms based on established evidence base*

affron® (Crocus sativus Stigma Extract, standardized to >3.5% Lepticrosalides®)

Dose: 28 mg Role: Neuroendocrine Resilience, Mood Balance & HPA-Axis Support

affron® is the most clinically studied standardized saffron extract for mood, emotional well-being, and stress resilience — with a research program spanning multiple human trials across diverse populations including perimenopausal women, adults with depressive symptoms, athletes, and adolescents.

Saffron's mood-supporting mechanisms are well-characterized: crocin and crocetin support serotonergic and dopaminergic signaling, safranal supports GABA-ergic tone, and affron® has been shown to support the body's endogenous melatonin production — addressing mood, stress response, and sleep quality through complementary neurochemical pathways.*

The 28 mg daily dose in HERgevity™ Balance matches the exact dose validated in the primary clinical trials.*

PoZibio® (Heat-Treated Lacticaseibacillus paracasei D3.5)

Dose: 50 mg Role: Gut–Hormone Axis Integrity & Microbiome Support

PoZibio® is a next-generation postbiotic derived from heat-treated Lacticaseibacillus paracasei D3.5 — with research origins at Wake Forest University. As a postbiotic, it delivers stable, consistent bioactive compounds derived from the bacterial strain without requiring live organisms to survive through manufacturing, storage, and digestion.*

In HERgevity™ Balance, PoZibio® addresses a dimension of women's hormonal health that most formulas miss entirely: the gut–hormone axis. Estrogen metabolism and clearance are profoundly influenced by gut microbiome composition and gut barrier integrity. An impaired gut barrier or dysbiotic microbiome can allow deconjugated estrogens to be reabsorbed into circulation rather than eliminated — a process that directly affects hormonal balance independent of anything happening at the receptor level.*

PoZibio® supports:*

• Gut mucin layer integrity and intestinal barrier structure*
• Healthy gut–hormone and gut–brain communication pathways*
• Microbiome balance that supports healthy estrogen clearance through glucuronidation*
• Healthy inflammatory tone in the intestinal environment that underpins hormone metabolism*

By addressing gut barrier integrity alongside the hormonal and neuroendocrine ingredients in HERgevity™ Balance, PoZibio® closes the loop on estrogen's full metabolic cycle — from production and signaling through clearance and elimination.*

Ioniplex® (Fulvic Ionic Mineral Complex)

Dose: 100 mg Role: Cellular Mineral Transport & Metabolic Foundation

Ioniplex® is a standardized fulvic ionic mineral complex that supports mineral delivery at the cellular level, mitochondrial energy production, and detoxification pathways involved in hormone metabolism.*

Hormone signaling, neurotransmitter synthesis, HPA-axis function, and stress resilience are all mineral-dependent processes. Magnesium, zinc, iron, and trace minerals serve as cofactors for the enzymes involved in estrogen synthesis, cortisol regulation, serotonin production, and cellular energy metabolism. Ioniplex® provides the cellular terrain and mineral transport support that makes these processes possible — functioning as the foundational layer that supports all other ingredients in the formula.*

AstraGin® (Astragalus membranaceus and Panax notoginseng Root Extracts)

Dose: 50 mg (containing Astragaloside I & IV and Ginsenoside Rb1) Role: Intestinal Nutrient Transport & Bioavailability

AstraGin® is a patented botanical blend with a well-established research profile for supporting intestinal nutrient absorption through upregulation of key nutrient transporter proteins.*

In HERgevity™ Balance, AstraGin® ensures that the active ingredients — Xeya™, MENOFELIS®, affron®, and PoZibio® — are absorbed efficiently and consistently. The clinical data supporting each of these ingredients was generated using bioavailable forms at specific doses. AstraGin® supports that bioavailability in real-world clinical use — bridging the gap between what the science shows and what the patient's gut actually absorbs.*

AstraGin® also supports gut barrier integrity and healthy inflammatory signaling in the intestinal environment, complementing PoZibio®'s gut axis support.*

HERgevity™ Balance is designed for women who want a non-hormonal, systems-based approach to hormonal health—one that supports emotional balance, gut integrity, and estrogen signaling without forcing hormonal outcomes. It is an ideal foundational formula for women navigating PMS, PCOS, perimenopause, menopause, or long-term hormonal resilience—especially when safety, adaptability, and whole-body health matter most.*

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