GlucoPrime™

Healthy glucose metabolism is not a single mechanism. GlucoPrime™ was not built as a single solution.*

Post-meal glucose handling, fasting glucose regulation, cellular glucose uptake, gut barrier integrity, and metabolic gene expression are separate but interconnected systems. A formula that addresses only one — a berberine product that targets AMPK, or a chromium supplement that supports insulin signaling — leaves the others unattended.

GlucoPrime™ was formulated as a systems-level metabolic support formula, where each ingredient plays a distinct, non-redundant role across these five interconnected pathways — working together to support metabolic resilience, glucose steadiness, and long-term cardiometabolic balance.*

Particularly relevant for patients navigating GLP-1 therapy, metabolic resilience goals, or the increasing clinical focus on glucose variability tracking.*

KEY SUPPORTED BENEFITS

GlucoPrime™ is formulated to support:*

• Healthy post-meal glucose responses and carbohydrate tolerance*
• Healthy fasting glucose and insulin levels*
• AMPK-related cellular glucose uptake and metabolic signaling*
• HNF4α-mediated metabolic gene expression — the "master metabolic switch"*
• Gut barrier integrity and gut–metabolic axis communication*
• Healthy inflammatory response signaling associated with metabolic health*
• Mitochondrial efficiency and cellular energy metabolism*
• Digestive comfort, including bloating and GI discomfort associated with metabolic therapies*

THE FIVE-PATHWAY METABOLIC SYSTEM

How GlucoPrime™ Addresses Metabolic Health

• Pathway 1 — Post-Meal Glucose Moderation (Gut Lumen) → Reducose®
• Pathway 2 — Upstream Metabolic Gene Expression (HNF4α) → BioMetaControl™
• Pathway 3 — Intracellular Metabolic Signaling (AMPK) → GlucoVantage®
• Pathway 4 — Gut Barrier & Incretin Signaling → Eriogut™ Pro
•  Pathway 5 — Mitochondrial Energy & Cellular Support → Naturalin® + Chromium

THE FORMULA — FIVE INGREDIENTS. FIVE BIOLOGICAL TARGETS.

Reducose® (White Mulberry Leaf Extract, standardized to 5% DNJ)

Dose: 250 mg Role: Post-Meal Glucose Moderation & Carbohydrate Tolerance Powered by Phynova

Reducose® is a patented white mulberry leaf extract standardized for 1-deoxynojirimycin (DNJ) — a naturally occurring compound that supports healthy post-prandial glucose handling through alpha-glucosidase inhibition. By slowing the enzymatic breakdown of complex carbohydrates in the small intestine, Reducose® moderates the rate of glucose absorption and supports a more gradual glycemic response after meals.*

This mechanism operates entirely in the gut lumen — upstream of the bloodstream — making it a complementary rather than redundant addition to any formula supporting cellular glucose metabolism downstream.*

Clinical Evidence — Double-Blind, Randomized, Placebo-Controlled Crossover Trial (Oxford Brookes, 2024, published in Nutrients):*

• 30–33% reduction in post-prandial blood glucose response versus placebo over 2 hours*
• 26–32% reduction in peak blood glucose response versus placebo*
• 31–38% reduction in total insulin release versus placebo*
• 27–40% reduction in peak insulin release versus placebo*
• Efficacy demonstrated at 200 mg, 225 mg, and 250 mg across a complete Western-style meal*
• Results consistent with prior clinical trials; reduction in post-prandial glucose not significantly impacted by total food quantity*

Reducose® is one of the most clinically studied post-meal glucose support ingredients available, with a body of research spanning multiple trial designs, meal compositions, and dosing levels.*

BioMetaControl™ (NCT + NFT Sustained-Release Complex)

Dose: 120 mg Role: HNF4α Metabolic Gene Expression Support — Upstream Glucose Regulation Powered by Brightseed · Forager® AI Discovery

BioMetaControl™ is Brightseed's first commercial metabolic health ingredient — built around two plant-derived bioactives, n-trans-Caffeoyl Tyramine (NCT) and n-trans-Feruloyl Tyramine (NFT), identified by Brightseed's Forager® AI platform as potent agonists of hepatocyte nuclear factor 4 alpha (HNF4α).*

HNF4α is a transcription factor widely recognized as the "master metabolic switch" — a central regulator of glucose sensing, insulin secretion, hepatic glucose production, and lipid metabolism. By activating HNF4α through natural plant bioactives rather than pharmaceutical intervention, BioMetaControl™ works upstream at the level of gene expression — supporting the body's own metabolic regulation machinery rather than forcing downstream changes in blood glucose.*

This mechanism operates at a fundamentally different biological level than alpha-glucosidase inhibition (Reducose®), AMPK activation (GlucoVantage®), or incretin signaling (Eriogut™ Pro) — making BioMetaControl™ a genuinely non-redundant contributor to the GlucoPrime™ formula.*

Clinical Evidence — Randomized, Double-Blind, Parallel-Arm Human Clinical Trial (n=126):*

• Statistically significant improvement in fasting blood glucose in prediabetic subjects within 30 days*
• Statistically significant improvement in fasting insulin levels within 30 days*
• Statistically significant improvement in post-meal glucose levels within 30 days*
• Integrated CGM data provided a comprehensive picture of glucose variability alongside fasting biomarkers*
• Digestive relief benefits (reduced bloating and GI discomfort) demonstrated in a separate published study at the same dose*
• Study results submitted to peer-reviewed journal; publication expected 2025/2026*

GLP-1 Companion Positioning: BioMetaControl™ was specifically developed and positioned as a GLP-1 companion ingredient — supporting glucose control and metabolic steadiness for patients using or transitioning from GLP-1 therapies, where maintaining blood sugar stability after discontinuation is an important clinical consideration.*

GlucoVantage® (Dihydroberberine)

Dose: 200 mg Role: AMPK Activation & Intracellular Metabolic Signaling by NNB Nutrition

GlucoVantage® is a highly bioavailable form of dihydroberberine (DHB) — the active metabolite that conventional berberine must first be converted into before absorption. By delivering the active form directly, GlucoVantage® achieves meaningful metabolic support at lower doses and with significantly improved gastrointestinal tolerability compared to standard berberine supplementation.*

DHB supports AMPK-related metabolic signaling — a critical intracellular pathway governing cellular glucose uptake, lipid metabolism, and mitochondrial energy efficiency. Where Reducose® slows glucose absorption in the gut and BioMetaControl™ activates upstream gene expression, GlucoVantage® supports the intracellular machinery that processes glucose once it enters cells — completing the circuit from meal to cell.

Eriogut™ Pro (High-Potency Citrus Flavonoids + Postbiotic)

Dose: 300 mg Role: Gut–Glucose Signaling Interface & Incretin Support

Eriogut™ Pro is a proprietary complex integrating high-potency citrus flavonoids — standardized to >70% eriocitrin and hesperidin — with a next-generation postbiotic component. It addresses metabolic health at the gut–glucose signaling interface: the site in the gastrointestinal tract where incretin signaling, barrier integrity, and inflammatory tone are first established.*

Eriocitrin and hesperidin support healthy incretin hormone activity — particularly GLP-1 release — which plays a central role in glucose-stimulated insulin secretion and post-meal metabolic coordination.* By working at the gut lumen level alongside Reducose® while supporting incretin signaling that complements GlucoVantage®'s cellular activity, Eriogut™ Pro is a genuinely upstream metabolic contributor.*

The postbiotic component supports gut barrier integrity, microbiome balance, and healthy inflammatory tone in the intestinal environment — the mucosal foundation that determines how effectively the gut communicates with the body's metabolic systems.*

Naturalin® (Highly Soluble Ellagic Acid with Choline) + Chromium Picolinate

Dose: Naturalin® 100 mg + Chromium 400 mcg Role: Antioxidant Defense, Mitochondrial Support & Insulin Signaling Naturalin® is a Healthgevity HCP Exclusive — sourced from Halo Life Science

Naturalin® is a patented ingredient developed by Halo Life Science that solves one of the most longstanding bioavailability challenges in polyphenol nutrition. Ellagic acid — found naturally in pomegranates, raspberries, and other plants — is one of the most multifunctional natural bioactives in the longevity and metabolic space. The problem: conventional ellagic acid has extremely poor water solubility (approximately 9 µg/ml), limiting its absorption and biological activity in standard oral formulations.*

Halo Life Science's proprietary process bonds ellagic acid to a choline base — creating Naturalin®, a choline salt of ellagic acid that is over 1,000 times more soluble than conventional ellagic acid. This dramatically improves absorption, fermentability, and downstream biological activity.*

Once absorbed, Naturalin® supports metabolic health through several interconnected mechanisms:*

Urolithin Production: Naturalin® serves as a highly bioavailable precursor to urolithins — the gut-derived postbiotics (including urolithins A, B, C, D and beyond) that drive meaningful benefits for mitochondrial function, muscle health, and metabolic resilience.* Halo's data demonstrates Naturalin® enables urolithin production over 1,000 times greater than conventional ellagic acid sources — making it a genuinely differentiated mitochondrial support ingredient.*

GLUT4 Signaling: In vitro research has shown Naturalin® signals and translocates GLUT4 proteins — the primary glucose transporter responsible for insulin-stimulated glucose uptake in muscle and adipose tissue — supporting cellular glucose uptake pathways.*

Alpha-Glucosidase Inhibition: Naturalin® inhibits alpha-glucosidase activity, contributing to healthy post-meal glucose handling through a complementary mechanism to Reducose®.*

Antioxidant & Redox Defense: Ellagic acid and its urolithin metabolites support cellular antioxidant defense and healthy inflammatory response signaling — contributing to the metabolic environment needed for efficient glucose handling and long-term cellular resilience.*

Naturalin® is available to Healthgevity practitioners as a Healthgevity HCP Exclusive — reflecting Healthgevity's direct sourcing relationship with Halo Life Science.

Chromium picolinate is one of the most studied and bioavailable forms of chromium — an essential trace mineral involved in carbohydrate and lipid metabolism. It supports normal insulin signaling and helps maintain healthy cellular glucose utilization — providing the essential mineral cofactor that underpins the insulin-glucose signaling cascade.*

CONTAINS: MILK (used in the fermentation process of BioMetaControl™)

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