First, we have included InnoSlim®, a proprietary blend of purified, fractionated extracts of Panax notoginseng and Astragalus root produced by a pharmaceutical-grade extraction technology which delivers astragalosides and ginsenosides Rg1 and Rb1. Research has shown it supports the production of adiponectin, a protein hormone that helps modulate metabolic processes such as glucose regulation and fatty acid metabolism. InnoSlim® reduces glucose absorption in the intestine by 42%. This means that only 58% of the glucose you eat will be absorbed in your intestine. In addition, InnoSlim® also increases glucose absorption in muscle and fat cells by 50% and 68% by upregulating GLUT4 transporters, which takes glucose from our blood and transfers it into the muscle tissue. InnoSlim® has also been shown to support appetite control, AMPK activation, insulin resistance, triglycerides and sdLDL in cell, animal and human studies. 

One other mechanism Ignite targets to improve our metabolic health and weight is to increase the energy expenditure of our bodies. Ignite delivers several ingredients in the formula which help our bodies do this process. Each of these has unique mechanisms of action but combine to make massive differences in the energy we use and how we process glucose in our bloodstream.

• MitoBurn® (L-BAIBA): Mitoburn® is an exercise mimetic, which mimics exercise’s effect on our tissues. This signals the body to help reduce fatty acids in our system, which are another energy source other than glucose. It can also help produce ketones which reduce appetite and improve energy output. It has also been shown to: Assist in the browning of white fat, activating AMPK, increasing metabolic rate, supporting leptin levels, and insulin resistance.
• GlucoVantage® Dihydroberberine: Dihydroberberine is a new version of traditional berberine that is up to 5x more bioavailable/absorbable and 2x longer lasting (8 hours vs. 4 hours). In one study, this led to 25.9% reduced blood glucose levels compared to the start of the trial in many patients. Dihydroberberine can also help with advanced glycation end products correlated with aging while supporting blood glucose disposal and improving insulin sensitivity and body composition.
• DNF-10 satiety peptide complex is obtained from a screening of small molecular weight peptides (<10 kDa) after proteolysis of Saccharomyces cerevisiae, a non-pathogenic yeast. The peptides from DNF-10 lower the hypothalamic expression of neuropeptide Y and downregulate ghrelin, thereby reducing the physiological hunger cues confirmed in multiple published studies.
• CalorieBurn GP® Grains of Paradise seed extract (6-Paradol 12.5%): CalorieBurn® contains bioactive compounds 6-paradol, 6-shogaol, 6-gingerol, and 6- gingerdione. These have been shown to effectively trigger highly thermogenic Brown Adipose Tissue (BAT) when taken in a precise ratio to one another, resulting in a 5X increase in calories burned over 2 hours compared to placebo. On average, burned 97 kcal more calories daily and lost more visceral fat. In another study, 40mg results in a 400% increase in metabolic rate within 30 minutes. Administration of this also reverses the unbalanced gut microbiota composition induced by a high-fat diet with a decrease in Firmicutes / Bacteroidetes ratio and increase in general Bifidobacterium and Akkermansia.
• Factor21® (Bitter Melon Extract): Factor21® is a natural regulator of a hormone growth factor called Fibroblast Growth Factor 21 (FGF21) and is an AMPK activator. FGF21 is a potent longevity factor coordinating interactions between energy metabolism and stress responses. Recent studies have revealed that supporting FGF21 can alleviate many age-related metabolic disorders. Factor21® is also an exercise mimetic that has many actions, including improved insulin secretion to drive glucose out of the bloodstream and inhibit fat cell growth.
• Actiponin® (gynostemma pentaphyllum extract): Actiponin® is a patented, clinically backed, natural fat loss ingredient derived from gynostemma pentaphyllum. The patented technology featured in Actiponin® makes it 10 times more potent than traditional gynostemma pentaphyllum extracts. The fundamental mechanism of Actiponin® is the activation of 5′ AMP-activated protein kinase (AMPK) which is typically activated by exercise and plays a crucial role in metabolic health by regulating fat-burning along with energy production.During 12 weeks of Actiponin® supplementation, total abdominal fat area, body weight, body fat mass, percent body fat, and BMI were significantly decreased. In this same study, waist circumference decreased on average 2.90 cm (1.1 inches) over 3 months.

Another recent study showed that 88% of Americans were metabolically unhealthy. Metabolic resistance is a concern for everyone as they try to improve their physical appearance and overall health. Ignite is a unique combination of clinically verified ingredients built to help optimize metabolic health and weight control. Together, these ingredients synergize to reduce the factors which lead to weight gain and insulin sensitivity to create the best metabolic control formulation on the market.

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Factor21® is a trademark of Verdure Sciences, Inc.