OMEGAgevity™ SPM+

Herring Caviar Oil with Bioactive SPMs

RESOLVE • REPAIR • RESTORE*

OMEGAgevity™ SPM+ is an advanced marine lipid formula designed to support the body’s natural resolution pathways—the active biological processes that help bring an inflammatory response to completion and support the return toward homeostasis.*

Unlike conventional omega-3 formulas focused primarily on delivering EPA and DHA, OMEGAgevity™ SPM+ provides a phospholipid-rich herring caviar marine lipid matrix with SPM pathway intermediates and bioactive Specialized Pro-Resolving Mediators (SPMs).

This multi-layered approach provides nutritional support at multiple points along the body’s natural pro-resolving lipid pathways.*

INFLAMMATION IS ONLY HALF THE STORY

An inflammatory response is designed to have a beginning—and an end.

For years, nutritional strategies have focused largely on influencing the initiation and intensity of inflammation. Research into resolution biology has expanded that understanding.

Resolution is not simply the passive disappearance of inflammatory signals. It is an actively regulated biological program that helps coordinate the transition from an inflammatory response back toward homeostasis.*

Specialized Pro-Resolving Mediators, or SPMs, are lipid-derived signaling molecules involved in this process.

They participate in pathways associated with limiting further inflammatory-cell recruitment, supporting cellular cleanup and helping coordinate tissue repair and restoration.*

OMEGAgevity™ SPM+ was designed around this next level of omega-3 biology.

THREE LEVELS OF RESOLUTION SUPPORT*

1 | PHOSPHOLIPID-RICH MARINE LIPID MATRIX

OMEGAgevity™ SPM+ begins with a naturally complex herring caviar marine lipid matrix.

Unlike conventional fish oils in which omega-3 fatty acids are commonly delivered predominantly as triglycerides, herring caviar provides marine omega-3s within a phospholipid-rich matrix.

Phospholipids are structural components of cell membranes, providing a biologically relevant lipid environment for EPA, DHA, and downstream lipid-mediator pathways.*

2 | SPM PATHWAY INTERMEDIATES

EPA and DHA can be enzymatically transformed into oxygenated lipid intermediates that sit along pathways leading toward specialized pro-resolving mediators.

OMEGAgevity™ SPM+ provides nine identified SPM pathway intermediates, including 18-HEPE, 17-HDHA, and 14-HDHA.

These compounds represent multiple points along EPA- and DHA-derived pro-resolving pathways.*

3 | BIOACTIVE SPMs

OMEGAgevity™ SPM+ also provides five identified bioactive SPMs from the resolvin, maresin, and protectin families.

Together, the phospholipid-rich marine matrix, pathway intermediates, and downstream mediators create a comprehensive resolution-focused lipid profile.*

MORE THAN PREFORMED SPMs

The emerging science behind herring roe lipids makes OMEGAgevity™ SPM+ particularly compelling.

A 2026 study published in the Journal of Lipid Research investigated phospholipid-rich herring roe lipids in human-derived macrophages and a keratinocyte/fibroblast coculture.

Researchers observed broad SPM biosynthesis, including prominent increases in E-series resolvins and increases in DHA-derived pro-resolving mediators under the experimental conditions.

Importantly, the findings were consistent with new cellular SPM biosynthesis, rather than simply the transfer of SPMs already present in the herring roe oil.

This suggests herring roe lipids may also support the body’s own SPM production, adding a fourth layer beyond the three above.

WHY PHOSPHOLIPIDS MATTER

The form in which marine omega-3s are delivered may influence how they behave in the body.

In a randomized crossover human study involving 32 adults, phospholipid-rich herring roe oil was compared with triglyceride-rich fish oil.

Following an acute dose, plasma phosphatidylcholine exposure to EPA, DHA, and EPA+DHA was significantly higher with the herring roe oil. After two weeks, both sources increased fasting plasma phosphatidylcholine omega-3 levels.

Researchers concluded that phospholipid-rich herring roe oil was a well-tolerated and bioavailable source of long-chain omega-3 fatty acids.

This human research supports the biological rationale for the phospholipid-rich herring caviar matrix used in OMEGAgevity™ SPM+.*

DESIGNED TO SUPPORT*

• Healthy resolution pathways

• A balanced inflammatory response

• Cellular cleanup and restoration

• Tissue repair and recovery pathways

• Healthy aging

• Musculoskeletal and joint wellness

• Cardiometabolic wellness

• Skin and barrier health

THE OMEGAGEVITY™ SPM+ PROFILE

1.5 g ACTIVE MARINE PHOSPHOLIPID CONCENTRATE

Per 3-softgel serving

SPM PATHWAY INTERMEDIATES

EPA-Derived

15-HEPE • 18-HEPE • 15-HpEPE • 5-HpEPE

DHA-Derived

7-HDHA • 10-HDHA • 14-HDHA • 17-HDHA • 17-HpDHA

BIOACTIVE SPMs

MaR1 — Maresin 1
MaR2 — Maresin 2
RvD5 — Resolvin D5
RvE2 — Resolvin E2
NPDx — Neuroprotectin Dx

THE HEALTHGEVITY DIFFERENCE

RESOLUTION-FOCUSED

Designed around the biology involved in bringing an inflammatory response toward completion—not simply influencing its initiation.*

MULTI-LAYERED APPROACH

Three levels of resolution support in one formula.

HERRING CAVIAR PHOSPHOLIPIDS

A distinctive marine lipid source providing omega-3 fatty acids within a naturally phospholipid-rich matrix.

HUMAN BIOAVAILABILITY RESEARCH

Phospholipid-rich herring roe oil has been evaluated in human research and demonstrated bioavailability of long-chain omega-3 fatty acids.

EMERGING 2026 SPM SCIENCE

Human-derived cellular research demonstrates that herring roe lipids can promote the biosynthesis of specialized pro-resolving mediators, expanding the scientific rationale beyond the preformed SPM content of the oil.

Contains: Fish (Herring)

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