GLUCOPRIME™ REFERENCES

Eriogut™ Pro:

Eriomin®

  • Cesar, Thais Borges et al. “Nutraceutical Eriocitrin (Eriomin) Reduces Hyperglycemia by Increasing Glucagon-Like Peptide 1 and Downregulates Systemic Inflammation: A Crossover-Randomized Clinical Trial.” Journal of medicinal food vol. 25,11 (2022): 1050-1058. doi:10.1089/jmf.2021.0181
  • Ramos, Fernanda M M et al. “Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double-blind randomized controlled trial.” Food science & nutrition vol. 11,11 7283-7295. 19 Sep. 2023, doi:10.1002/fsn3.3654
  • Ribeiro, Carolina B et al. “Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study.” Phytotherapy research : PTR vol. 33,7 (2019): 1921-1933. doi:10.1002/ptr.6386
  • Cesar, Thais et al. “Citrus flavonoid supplement enhances glycemic and metabolic control in prediabetic patients on metformin: a randomized controlled trial.” Frontiers in nutrition vol. 12 1639901. 19 Aug. 2025, doi:10.3389/fnut.2025.1639901

Hesperidin

  • Xiong, Haijun et al. “Hesperidin: A Therapeutic Agent For Obesity.” Drug design, development and therapyvol. 13 3855-3866. 12 Nov. 2019, doi:10.2147/DDDT.S227499
  • Tejada, Silvia et al. “Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus.” Current medicinal chemistry vol. 25,37 (2018): 4929-4945. doi:10.2174/0929867324666170718104412
  • Li, Chaoyun, and Hermann Schluesener. “Health-promoting effects of the citrus flavanone hesperidin.” Critical reviews in food science and nutrition vol. 57,3 (2017): 613-631. doi:10.1080/10408398.2014.906382

PoZibio® Postbiotic (Heat-Treated Lacticaseibacillus paracasei D3.5)

  • Wang, Shaohua et al. “Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice.” GeroScience vol. 42,1 (2020): 333-352. doi:10.1007/s11357-019-00137-4
  • Żółkiewicz J, Marzec A, Ruszczyński M, Feleszko W. Postbiotics—A Step Beyond Pre- and Probiotics. Nutrients. 2020; 12(8):2189. https://doi.org/10.3390/nu12082189
  • Ma, Linxi et al. “Postbiotics in Human Health: A Narrative Review.” Nutrients vol. 15,2 291. 6 Jan. 2023, doi:10.3390/nu15020291
  • Nagpal, Ravinder et al. “Gut microbiome and aging: Physiological and mechanistic insights.” Nutrition and healthy aging vol. 4,4 267-285. 15 Jun. 2018, doi:10.3233/NHA-170030
  • Nataraj, Basavaprabhu H et al. “Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods.” Microbial cell factories vol. 19,1 168. 20 Aug. 2020, doi:10.1186/s12934-020-01426-w

Brightseed® BioMetaControl™ (NCT + NFT) – 120 mg

  • Melo, Luma & Bolster, Douglas & Kalgaonkar, Swati & Chae, Lee & Treadway, Sam & Chinta, Sowmya & Bloor, Sarah & Black, Haddasah & D’Adamo, Christopher & Coy, Elizabeth & Hobson, Anthony. (2025). Effects of N-Trans Caffeoyltyramine and N-Trans Feruloyltyramine supplementation in individuals with diarrhea predominant-irritable bowel syndrome: Randomized, double-blind, placebo-controlled trial. Bioactive Compounds in Health and Disease - Online ISSN: 2574-0334; Print ISSN: 2769-2426. 8. 204-217. 10.31989/bchd.v8i6.1655.
  • Shlisky, Julie et al. “Bioavailability and Metabolism of N-Trans Caffeoyltyramine and N-Trans Feruloyltyramine - A Narrative Review.” Journal of dietary supplements vol. 23,1 (2026): 101-117. doi:10.1080/19390211.2025.2597203
  • van Klinken, B Jan-Willem et al. “Health-Promoting Opportunities of Hemp Hull: The Potential of Bioactive Compounds.” Journal of dietary supplements vol. 21,4 (2024): 543-557. doi:10.1080/19390211.2024.2308264
  • Flores Martinez, Karla E et al. “Hemp hull fiber and two constituent compounds, N-trans-caffeoyltyramine and N-trans-feruloyltyramine, shape the human gut microbiome in vitro.” Food chemistry: X vol. 23 101611. 2 Jul. 2024, doi:10.1016/j.fochx.2024.101611

Reducose® (White Mulberry Leaf Extract, standardized to 5% DNJ) 

  • Soon et al., 2025. Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints – A randomized cross‑over study. European Journal of Nutrition, 64: 124. Click to read paper
  • Thondre et al., 2024. Understanding the Impact of Different Doses of Reducose® Mulberry Leaf Extract on Blood Glucose and Insulin Responses after Eating a Complex Meal: Results from a Double-Blind, Randomised, Crossover Trial. Nutrients, 16, 1670. Click to read paper
  • Lee et al., 2024. Glucose-lowering effect of Reducose® enriched with 1-deoxynojirimycin and L-leucine: Studies on insulin secretion in INS-1 cells and reduction of blood glucose in diabetic rats. Heliyon, 10: e25499.  Click to read paper
  • Hester et al., 2023. Effects of a Dietary Supplement Focused on Blood Glucose Control To Assist in Weight Management That Impacts Appetite, Hunger, and Satiety. Current Developments in Nutrition, 7 (Suppl 1): 101589 (Poster presentation). Click to read abstract
  • Schillinger et al., 2023. 13C-sucrose breath test for the non-invasive assessment of environments enteropathy in Zambian adults. Frontiers in Medicine, 9: 904339. (paper demonstrates undigested carbohydrates feed microbiome) Click to read paper
  • Ding et al., 2023. The impact of mulberry leaf extract at three different levels on reducing the glycemic index of white bread.  PLoS ONE, 18 (8): e0288911. Click to read paper
  • Mohamed et al., 2022. A Randomized, Placebo-Controlled Crossover Study to Evaluate the Effect of a Natural Powder Blend (Mulberry Leaf Extract [MLE], Vitamin D, Chromium, and Fiber) on Postprandial (PP) Metabolic Response in Type 2 Diabetes (T2D). Diabetes; 71 (Supplement 1): 41-LB. Click to read abstract for poster.
  • Gheldof et al., 2022.  Effect of different nutritional supplements on glucose response of complete meals in two crossover studies. Nutrients; 14: 2674. Click to read paper
  • Thondre et al, 2021. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomised, double-blind, placebo-controlled study. Nutrition & Metabolism; 18:41.  Click to read paper
  • Wang et al, 2018. Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates. Medicine (2018) 97:34.  Click to read paper
  • Li et al., 2018. Safety evaluation of mulberry leaf extract: acute, subacute toxicity and genotoxicity studies. Regulatory Toxicology and Pharmacology; 95: 220-226. Click to read paper
  • Lown et al, 2017. Mulberry extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: results of a randomized double-blind placebo controlled study. PLOS ONE. Click to read paper.   

Naturalin® (Highly Soluble Ellagic Acid with Choline)

  • Maleki, Vahid et al. “Potential roles of ellagic acid on metabolic variables in diabetes mellitus: A systematic review.” Clinical and experimental pharmacology & physiology vol. 50,2 (2023): 121-131. doi:10.1111/1440-1681.13729
  • Ghazaee, Hossein et al. “Ellagic acid as potential therapeutic compound for diabetes and its complications: a systematic review from bench to bed.” Naunyn-Schmiedeberg's archives of pharmacology vol. 397,12 (2024): 9345-9366. doi:10.1007/s00210-024-03280-8
  • Zhang, Mengwei et al. “Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation.” Critical reviews in food science and nutrition vol. 63,24 (2023): 6900-6922. doi:10.1080/10408398.2022.2036693
  • Ríos, José-Luis et al. “A Pharmacological Update of Ellagic Acid.” Planta medica vol. 84,15 (2018): 1068-1093. doi:10.1055/a-0633-9492
  • Senavirathna T, Shafaei A, Lareu R, Balmer L. Unlocking the Therapeutic Potential of Ellagic Acid for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. Antioxidants. 2024; 13(4):485. https://doi.org/10.3390/antiox13040485

GlucoVantage® (Dihydroberberine)

  • Zhang, Chenyang et al. “Dihydroberberine normalizes insulin secretion by regulating glucokinase.” Diabetes, obesity & metabolism vol. 28,1 (2026): 151-165. doi:10.1111/dom.70171
  • Chang, Chuck et al. “Differences in Metabolite Profiles of Dihydroberberine and Micellar Berberine in Caco-2 Cells and Humans-A Pilot Study.” International journal of molecular sciences vol. 25,11 5625. 22 May. 2024, doi:10.3390/ijms25115625
  • Gasmi, Amin et al. “Berberine: Pharmacological Features in Health, Disease and Aging.” Current medicinal chemistry vol. 31,10 (2024): 1214-1234. doi:10.2174/0929867330666230207112539
  • Shi, Lanjun et al. “Berberine and health outcomes: an overview of systematic reviews.” BMC complementary medicine and therapies vol. 25,1 147. 23 Apr. 2025, doi:10.1186/s12906-025-04872-4

Chromium (as Chromium Picolinate) 

  • Maret, Wolfgang. “Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes.” Metal ions in life sciences vol. 19 (2019): /books/9783110527872/9783110527872-015/9783110527872-015.xml. doi:10.1515/9783110527872-015
  • Hummel, M et al. “Chromium in metabolic and cardiovascular disease.” Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme vol. 39,10 (2007): 743-51. doi:10.1055/s-2007-985847
  • Broadhurst, C Leigh, and Philip Domenico. “Clinical studies on chromium picolinate supplementation in diabetes mellitus--a review.” Diabetes technology & therapeutics vol. 8,6 (2006): 677-87. doi:10.1089/dia.2006.8.677
  • Willoughby, Darryn et al. “Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review.” Nutrients vol. 10,12 1876. 3 Dec. 2018, doi:10.3390/nu10121876