Serenity References

DHH-B ( Dihydrohonokiol-B) from Magnolia Bark:

  • Shen, Jui-Lung et al. “Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders.”Molecules (Basel, Switzerland)  15,9 6452-65. 16 Sep. 2010, doi:10.3390/molecules15096452

  • Lin, Yiping et al. “Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update.”Frontiers in pharmacology  12 632767. 17 Mar. 2021, doi:10.3389/fphar.2021.632767

  • Arora, S et al. “Honokiol: a novel natural agent for cancer prevention and therapy.”Current molecular medicine  12,10 (2012): 1244-52. doi:10.2174/156652412803833508

  • Dai, Xiaolin et al. “The Neuropharmacological Effects of Magnolol and Honokiol: A Review of Signal Pathways and Molecular Mechanisms.”Current molecular pharmacology  16,2 (2023): 161-177.doi:10.2174/1874467215666220223141101

  • Woodbury, Anna et al. “Neuro-modulating effects of honokiol: a review.”Frontiers in neurology  4 130. 11 Sep. 2013, doi:10.3389/fneur.2013.00130

  • Liu, Bing et al. “Anxiolytic agent, dihydrohonokiol-B, recovers amyloid beta protein-induced neurotoxicity in cultured rat hippocampal neurons.”Neuroscience letters  384,1-2 (2005): 44-7. doi:10.1016/j.neulet.2005.04.081

Holixer™ Holy Basil Extract :

  • Cohen MM. Tulsi - Ocimum sanctum: A herb for all reasons.J Ayurveda Integr Med. 2014;5(4):251-259. doi:10.4103/0975-9476.146554

  • Jamshidi, N., & Cohen, M. M. (2017). The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature.Evidence-based complementary and alternative medicine : eCAM, 2017, 9217567. https://doi.org/10.1155/2017/9217567

  • Lopresti, Adrian L et al. “A randomized, double-blind, placebo-controlled trial investigating the effects of anOcimum tenuiflorum (Holy Basil) extract (HolixerTM) on stress, mood, and sleep in adults experiencing stress.” Frontiers in nutrition  9 965130. 2 Sep. 2022, doi:10.3389/fnut.2022.965130

  • C M, Mohan Gowda et al. “Ocimum tenuiflorum extract (HOLIXER): Possible effects on hypothalamic-pituitary-adrenal (HPA) axis in modulating stress.”PloS one  18,5 e0285012. 4 May. 2023, doi:10.1371/journal.pone.0285012

Natural GABA probiotic  L. plantarum 815 (LP815™)

  • Hepsomali, Piril et al. “Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.”Frontiers in neuroscience  14 923. 17 Sep. 2020, doi:10.3389/fnins.2020.00923
  • Yamatsu, Atsushi et al. “Effect of oral γ-aminobutyric acid (GABA) administration on sleep and its absorption in humans.”Food science and biotechnology  25,2 547-551. 30 Apr. 2016, doi:10.1007/s10068-016-0076-9
  • Yamatsu, Atsushi et al. “The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract.”Journal of nutritional science and vitaminology  61,2 (2015): 182-7. doi:10.3177/jnsv.61.182
  • Abdou, Adham M et al. “Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans.”BioFactors (Oxford, England)  26,3 (2006): 201-8. doi:10.1002/biof.5520260305

Saffron Extract (as affron®)

  • Lopresti, Adrian L et al. “An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study.”Sleep medicine  86 (2021): 7-18. doi:10.1016/j.sleep.2021.08.001
  • Lopresti, Adrian L, and Stephen J Smith. “An examination into the mental and physical effects of a saffron extract (affron®) in recreationally-active adults: A randomized, double-blind, placebo-controlled study.”Journal of the International Society of Sports Nutrition  19,1 219-238. 7 Jun. 2022, doi:10.1080/15502783.2022.2083455
  • Orio, Laura et al. “Antianhedonic and Antidepressant Effects of Affron®, a Standardized Saffron (Crocus Sativus) Extract.” Molecules (Basel, Switzerland)vol. 25,14 3207. 15 Jul. 2020, doi:10.3390/molecules25143207
  • Lopresti, Adrian L, and Stephen J Smith. “The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study.”Journal of menopausal medicine  27,2 (2021): 66-78. doi:10.6118/jmm.21002
  • Lopresti, Adrian L et al. “Efficacy of a standardised saffron extract (affron®) as an add-on to antidepressant medication for the treatment of persistent depressive symptoms in adults: A randomised, double-blind, placebo-controlled study.”Journal of psychopharmacology (Oxford, England) 33,11 (2019): 1415-1427. 
  • Lopresti AL, Smith SJ, Metse AP, Drummond PD. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. J Clin Sleep Med. 2020 Jun 15;16(6):937-947. doi: 10.5664/jcsm.8376. PMID: 32056539; PMCID: PMC7849671.

L-Theanine (as L-TeaActive®)

  • Hidese, Shinsuke et al. “Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.”Nutrients  11,10 2362. 3 Oct. 2019, doi:10.3390/nu11102362
  • Hidese, Shinsuke et al. “Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study.”Acta neuropsychiatrica  29,2 (2017): 72-79. doi:10.1017/neu.2016.33
  • White, David J et al. “Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.”Nutrients  8,1 53. 19 Jan. 2016, doi:10.3390/nu8010053