HERgevity™ Balance References

Xeya™ Modern Shatavari (Asparagus racemosus) – 100 mg

  • Yadav, Poonam et al. “A Standardized Asparagus Racemosus Root Extract Improves Hormonal Balance and Menstrual Health and Reduces Vasomotor Symptoms in Perimenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Study.” Journal of the American Nutrition Associationvol. 44,8 (2025): 754-764.
  • Kondamudi, Sridevi et al. “CL22209, a standardized Asparagus racemosus root extract, demonstrates improved ovarian morphology, menstrual regularity, and metabolic parameters in women with polycystic ovary syndrome in a randomized, controlled trial.” Food & nutrition research vol. 69 10.29219/fnr.v69.13244. 23 Dec. 2025,
  • Nadeem, Mohd et al. “Exploring the neuroprotective role of Asparagus racemosus (Shatavari) in Alzheimer's disease: mechanisms, evidence, and future directions.” 3 Biotech vol. 15,7 (2025): 197. doi:10.1007/s13205-025-04355-w

MENOFELIS® Rhapontic Rhubarb Root Extract – 4 mg

  • Kaszkin-Bettag, Marietta et al. “Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study.” Alternative therapies in health and medicine vol. 14,6 (2008): 32-8.
  • Heger, Peter W et al. “Association between Extract Rheum rhaponticum 731 (ERr 731) prescription and subsequent breast cancer.” Breast cancer research and treatment vol. 212,1 (2025): 139-148. doi:10.1007/s10549-025-07711-9
  • Kaszkin-Bettag, Marietta et al. “Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms.” Alternative therapies in health and medicine vol. 15,1 (2009): 24-34.
  • Dubey, Vishal P et al. “Efficacy evaluation of standardized Rheum rhaponticum root extract (ERr 731 ®) on symptoms of menopause: A systematic review and meta-analysis study.” Journal of biomedical research vol. 38,3 (2024): 278-286. doi:10.7555/JBR.37.20230219
  • Kaszkin-Bettag, Marietta et al. “The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women.” Menopause (New York, N.Y.) vol. 14,2 (2007): 270-83. doi:10.1097/01.gme.0000251932.48426.35
  •  Prior, Jerilynn C et al. “Effectiveness of ERr 731 in the management of symptomatic perimenopause: clinical significance.” Menopause (New York, N.Y.) vol. 14,2 (2007): 335-6; author reply 336-8. doi:10.1097/GME.0b013e318032aaa9
  • Chang, Jyh-Lurn et al. “Rheum rhaponticum Extract (ERr 731): Postmarketing Data on Safety Surveillance and Consumer Complaints.” Integrative medicine (Encinitas, Calif.) vol. 15,3 (2016): 34-9.

affron® Saffron Extract (Crocus sativus) – 28 mg

  • Lopresti, Adrian L, and Stephen J Smith. “The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study.” Journal of menopausal medicine vol. 27,2 (2021): 66-78. doi:10.6118/jmm.21002
  • Kell, Graham et al. “affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial.” Complementary therapies in medicine vol. 33 (2017): 58-64. doi:10.1016/j.ctim.2017.06.001
  •  Lopresti, Adrian L et al. “An Examination into the Effects of a Saffron Extract (Affron) on Mood and General Wellbeing in Adults Experiencing Low Mood: A Randomized, Double-Blind, Placebo-Controlled Trial.” The Journal of nutrition vol. 155,7 (2025): 2300-2311. doi:10.1016/j.tjnut.2025.05.024
  • Lopresti, Adrian L, and Stephen J Smith. “An examination into the mental and physical effects of a saffron extract (affron®) in recreationally-active adults: A randomized, double-blind, placebo-controlled study.” Journal of the International Society of Sports Nutrition vol. 19,1 219-238. 7 Jun. 2022, doi:10.1080/15502783.2022.2083455
  • El Midaoui, Adil et al. “Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases.” Nutrients vol. 14,3 597. 29 Jan. 2022, doi:10.3390/nu14030597

PoZibio® Postbiotic (Heat-Treated Lacticaseibacillus paracasei D3.5) – 50 mg

  • Wang, Shaohua et al. “Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice.” GeroScience vol. 42,1 (2020): 333-352. doi:10.1007/s11357-019-00137-4
  •  Żółkiewicz J, Marzec A, Ruszczyński M, Feleszko W. Postbiotics—A Step Beyond Pre- and Probiotics. Nutrients. 2020; 12(8):2189. https://doi.org/10.3390/nu12082189
  • Ma, Linxi et al. “Postbiotics in Human Health: A Narrative Review.” Nutrients vol. 15,2 291. 6 Jan. 2023, doi:10.3390/nu15020291
  • Nagpal, Ravinder et al. “Gut microbiome and aging: Physiological and mechanistic insights.” Nutrition and healthy aging vol. 4,4 267-285. 15 Jun. 2018, doi:10.3233/NHA-170030
  •  Nataraj, Basavaprabhu H et al. “Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods.” Microbial cell factories vol. 19,1 168. 20 Aug. 2020, doi:10.1186/s12934-020-01426-w

AstraGin® (Astragalus membranaceus & Panax notoginseng) Root Extracts – 50 mg

  • Zhou P, Xie W, Sun Y, Dai Z, Li G, Sun G, Sun X. Ginsenoside Rb1 and mitochondria: A short review of the literature. Mol Cell Probes. 2019 Feb;43:1-5. doi: 10.1016/j.mcp.2018.12.001. Epub 2018 Dec 4. Erratum in: Mol Cell Probes. 2020 Dec;54:101626. PMID: 30529056.
  • Chang, Tsu-Chung et al. “Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression.” Journal of agricultural and food chemistry vol. 55,5 (2007): 1993-8. doi:10.1021/jf062714k
  • Wang, Chun-Wen et al. “A gut microbial metabolite of ginsenosides, compound K, induces intestinal glucose absorption and Na(+) /glucose cotransporter 1 gene expression through activation of cAMP response element binding protein.” Molecular nutrition & food research vol. 59,4 (2015): 670-84. doi:10.1002/mnfr.201400688
  • Huang, Su-Fen & Shen, You-Cheng & Ou, Ching-Hui & Tang, I-Chu & Yang, Han-Wen & Kao, Yu-Ting & Chang, Wen-Liang & Chang, Tsu-Chung. (2023). Astragalus membranaceus and Panax notoginseng saponins improves intestinal L-arginine absorption and protects against intestinal disorder in vivo. Food Science and Technology Research. 29. 10.3136/fstr.FSTR-D-22-00116.

Ioniplex® Fulvic Ionic Mineral Complex – 100 mg

US Patent No. 8,709,497: Title: Mineral, Cosmetic, Pharmaceutical, and Agriculture Compositions and Methods for Producing the Same  

US Patent No. 8,927,031: Title: Anti-Glycation Methods and Compositions  

US Patent No. 11103001: Title: Methods and Compositions for Modulating Muscle and Bone Loss