Brain Boost+

Brain Boost+ — Advanced Focus, Energy & Cognitive Performance Support

Brain Boost+ — Advanced Focus, Energy & Cognitive Performance Support

Most cognitive formulas give you caffeine with a label on it. Brain Boost+ was built differently.*

Caffeine works — but it comes with a fundamental limitation: about 59% of people are slow caffeine metabolizers, meaning they experience more side effects — jitteriness, anxiety, elevated heart rate, poor sleep — than cognitive benefit. And for everyone, caffeine's effects are shaped by individual CYP1A2 genetic variation, making consistent performance unpredictable.

Brain Boost+ builds its energy and focus foundation on paraxanthine — the primary active metabolite of caffeine that delivers caffeine's cognitive benefits through a cleaner mechanism, without the side effects that limit caffeine's usefulness for a significant portion of the population.*

Combined with GeniusPure® Alpha-GPC for cholinergic memory and processing support, Lion's Mane for neurological maintenance and long-term brain health, N-Acetyl L-Tyrosine for neurotransmitter precursor support, and L-TeaActive® L-Theanine for calm focus — Brain Boost+ targets five distinct neurophysiological pathways in a single formula designed for mental clarity, sustained energy, and cognitive resilience without overstimulation.*

KEY SUPPORTED BENEFITS

Brain Boost+ is formulated to support:*

• Sustained mental energy, alertness, and focused attention*
• Memory, cognitive processing speed, and working memory capacity*
• Healthy neurotransmitter balance — cholinergic, catecholaminergic, and GABAergic*
• Calm, focused energy without jitteriness, anxiety, or post-stimulant crash*
• Cognitive performance under pressure, during multitasking, and after physical exertion*
• Long-term neuronal health and nerve growth factor pathway support*
• Mood, motivation, and cognitive drive*

THE FIVE-PATHWAY COGNITIVE SYSTEM

• Adenosine Modulation & Mental Energy → enfinity® Paraxanthine
• Cholinergic Memory & Processing → GeniusPure® Alpha-GPC
• Neuronal Health & NGF Support → Lion's Mane (Hericium erinaceus)
• Catecholamine Precursor Support → N-Acetyl L-Tyrosine (NALT)
•  Alpha-Wave Calm Focus → L-TeaActive® L-Theanine

THE FORMULA

enfinity® Paraxanthine

Dose: 200 mg Role: Adenosine Receptor Modulation, Wakeful Alertness & Clean Mental Energy 

Paraxanthine is the primary active metabolite of caffeine — the compound your liver converts approximately 70% of caffeine into before it produces its cognitive effects. When you drink coffee and experience improved focus and alertness, it is largely paraxanthine doing the work. enfinity® delivers paraxanthine directly, bypassing the caffeine-to-paraxanthine conversion step — and with it, bypassing the side effects that caffeine itself — not paraxanthine — is responsible for.*

The clinical advantage of paraxanthine over caffeine is now established across four human clinical trials:*

The most fundamental advantage: paraxanthine's effects are consistent regardless of CYP1A2 genetic variation — the enzyme that metabolizes caffeine. Slow metabolizers (approximately 59% of the population) experience disproportionate side effects from caffeine, including cardiovascular stimulation, anxiety, and disrupted sleep. Since paraxanthine bypasses this metabolic step, its effects are predictable across metabolizer types.*

Clinical Evidence — Human Trials (enfinity®):*

Study 1 (Yoo et al., 2021, Nutrients): Single 200 mg dose, randomized double-blind placebo-controlled crossover (n=13). Paraxanthine produced significant improvements in memory, reaction time, and attention over 6 hours versus placebo.*

Study 2 (Yoo et al., 2024): Post-10km run cognitive performance, randomized double-blind crossover. Paraxanthine produced greater improvement in cognitive function and psychomotor vigilance than caffeine after exercise. Caffeine increased perceptions of tachycardia, shortness of breath, and nervousness post-exercise; paraxanthine did not.*

Studies 3 & 4: Across the four-study clinical program, paraxanthine consistently increased measures of cognition, memory, reasoning, response time, and sustained attention versus placebo.*

In head-to-head comparison with caffeine, enfinity® paraxanthine enables faster task-switching under cognitively stressful conditions — a specific operational advantage caffeine does not share.*

GeniusPure® Alpha-GPC (Alpha-Glycerophosphocholine, 90%)

Dose: 350 mg (delivering 315 mg active Alpha-GPC) Role: Cholinergic Memory, Processing Speed & Cognitive Sharpness 

Alpha-GPC is the most bioavailable dietary source of choline — the essential nutrient that is the direct precursor to acetylcholine, the neurotransmitter central to memory formation, learning, and cognitive processing speed. Unlike lower-bioavailability choline sources (choline bitartrate, CDP-choline), Alpha-GPC crosses the blood-brain barrier efficiently, directly supporting acetylcholine synthesis where it is needed most.*

GeniusPure® is a 90% pure Alpha-GPC from NNB Nutrition — one of the highest-purity forms available commercially, and the specific form tested in the 2024 randomized, double-blind, placebo-controlled crossover clinical trial.*

Clinical Evidence — GeniusPure® (Kerksick et al., 2024, Nutrients):*

• Randomized, double-blind, placebo-controlled, crossover trial in 20 healthy adults
• 350 mg dose (LD): statistically significant improvement in Stroop Total Score versus placebo, a validated measure of processing speed and cognitive interference control*
• 108% improvement in focus measures versus placebo at the 350 mg dose in manufacturer-sponsored study data*
• 140% improvement in processing speed versus placebo at the 700 mg dose*
• 16.7% higher self-reported alertness versus placebo*
• Results are consistent with the broader Alpha-GPC literature: a 2023 systematic review and meta-analysis pooling 7 randomized controlled trials confirmed Alpha-GPC significantly improves cognition and behavioral outcomes*

Alpha-GPC also supports brain cell membrane integrity through phospholipid precursor activity, and is associated with healthy growth hormone secretion — relevant for practitioners recommending this in older adult and active patient populations.*

Lion's Mane (Hericium erinaceus) Fruiting Body Extract

Dose: 500 mg (standardized fruiting body) Role: Neuronal Health, NGF Pathway Support & Long-Term Cognitive Resilience

Lion's Mane is one of the most thoroughly studied nootropic mushrooms for long-term brain health. Its primary bioactive compounds — hericenones (from the fruiting body) and erinacines (from mycelium) — are the subject of significant research for their role in supporting nerve growth factor (NGF) synthesis and neuronal maintenance.*

NGF is a protein essential for the growth, maintenance, and survival of neurons — particularly in the hippocampus and basal forebrain regions critical to memory and learning. NGF levels tend to decline with age, and supporting NGF pathway activity is increasingly recognized as relevant to healthy cognitive aging.*

In Brain Boost+, Lion's Mane provides the long-term neurological maintenance layer alongside paraxanthine's and Alpha-GPC's acute cognitive performance effects — addressing both immediate performance and the neurological foundation that supports it over time.*

Lion's Mane uses the organically cultivated fruiting body extract — the part of the mushroom where hericenones are concentrated, and the form used in the strongest published research on its neurological benefits.*

N-Acetyl L-Tyrosine (NALT)

Dose: 300 mg Role: Catecholamine Precursor — Dopamine, Norepinephrine & Cognitive Drive

L-Tyrosine is the direct amino acid precursor to the catecholamine neurotransmitters dopamine and norepinephrine — the primary neurochemicals of motivation, alertness, and cognitive drive. Under conditions of cognitive stress, multitasking, or sleep deprivation, catecholamine availability can become a limiting factor for mental performance.

N-Acetyl L-Tyrosine (NALT) is a more bioavailable form of L-Tyrosine, with improved water solubility and absorption compared to free-form L-Tyrosine. By supporting catecholamine synthesis, NALT helps maintain the neurochemical substrates for sustained motivation, alertness, and cognitive flexibility under demanding conditions.*

NALT works in complementary rather than redundant fashion with paraxanthine's adenosine modulation — paraxanthine removes the adenosine brake on alertness, while NALT provides the catecholamine fuel for mental drive and task engagement.*

L-TeaActive® L-Theanine

Dose: 200 mg Role: Alpha-Wave Calm Focus & Stimulant Smoothing 

L-Theanine is a naturally occurring amino acid concentrated in green and black tea, well-established for its ability to promote relaxed alertness without sedation through alpha brain-wave activity modulation.*

At 200 mg — matched 1:1 with paraxanthine — L-Theanine works synergistically with enfinity® paraxanthine in a relationship that mirrors the well-studied caffeine-theanine combination, but with paraxanthine's cleaner profile. L-Theanine modulates the excitatory aspects of paraxanthine-driven alertness, smoothing the onset, extending the duration, and reducing any edge that might accompany stimulant-class ingredients.*

Clinical evidence for L-Theanine across multiple human trials demonstrates:*

• Relaxation without drowsiness, measured by alpha brain-wave activity*
• Balanced mood and reduction of stress perception*
• Improvement in cognitive accuracy during attention tasks*
• Enhanced synergy with stimulant-class ingredients for focus and working memory*

L-TeaActive® is a standardized, high-purity L-Theanine with consistent potency per serving.*

HOW BRAIN BOOST+ WORKS DIFFERENTLY FROM CAFFEINE-BASED FORMULAS

Most cognitive supplements are caffeine delivery systems with supporting ingredients. Brain Boost+ inverts this architecture:

The energy and focus foundation is paraxanthine — caffeine's active metabolite — not caffeine itself. This means the formula's core mechanism is consistent across genetic metabolizer types, produces no cardiovascular overstimulation signal, and does not contribute to caffeine tolerance accumulation.*

The cholinergic memory layer is GeniusPure® Alpha-GPC — a clinically studied, 90%-pure choline source with acute cognitive performance data in healthy adults.*

The neurotransmitter precursor layer is NALT — ensuring the catecholamine pathways that drive motivation and cognitive drive have the substrate they need under cognitive load.*

The long-term neurological layer is Lion's Mane fruiting body — supporting the NGF pathways and neuronal maintenance that underpin durable cognitive health, not just today's performance.*

The balance and sustainability layer is L-TeaActive® L-Theanine — ensuring the formula delivers calm, sustained focus rather than acute stimulation.*

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