Ignite+

Metabolic aging is not a single problem. Ignite+ was not built as a single solution.*

Declining AMPK activity, accumulating visceral adiposity, deteriorating insulin sensitivity, weakening thermogenic capacity, reduced exercise-mimetic signaling, and dysregulated appetite hormones are separate but interconnected processes. A formula that addresses only one — a berberine product that targets glucose, or a thermogenic that raises heart rate — leaves the larger metabolic picture unaddressed.

Ignite+ was formulated as a systems-level metabolic optimization formula — seven clinically studied, patented ingredients targeting distinct and non-redundant metabolic pathways. No stimulants. No hormonal intervention. Just precision metabolic signaling designed for practitioners who understand that lasting metabolic health requires addressing the full spectrum of underlying mechanisms.*

KEY SUPPORTED BENEFITS

Ignite+ is formulated to support:*

• Healthy AMPK activation — the body's "metabolic master switch"*
• Brown adipose tissue (BAT) thermogenesis and healthy calorie expenditure*
• Browning of white adipose tissue (WAT) to support metabolic rate*
• Healthy glucose metabolism, insulin signaling, and glucose uptake in muscle tissue*
• Healthy visceral fat metabolism and body composition*
• Satiety signaling and healthy appetite hormone balance (ghrelin/leptin)*
• FGF21-mediated energy expenditure and metabolic homeostasis*
• Mitochondrial efficiency and cellular energy metabolism*

THE SEVEN-PATHWAY METABOLIC SYSTEM

How Ignite+ Addresses Metabolic Health:

• Satiety Signaling → DNF-10® (neuropeptide Y modulation, ghrelin balance)
• Glucose Metabolism → GlucoVantage® (AMPK, insulin signaling, glucose uptake)
• Exercise-Mimetic Signaling → MitoBurn® L-BAIBA (fat browning, fatty acid oxidation)
• GLUT4 & Glucose Absorption → InnoSlim® (intestinal glucose reduction, muscle uptake)
• FGF21 & Longevity Hormone Support → Factor21® (energy expenditure, adiponectin)
• AMPK Activation & Body Composition → Actiponin® (12-week clinical evidence)
• BAT Thermogenesis → CalorieBurn GP® (brown adipose tissue activation)

 THE FORMULA — SEVEN INGREDIENTS. SEVEN BIOLOGICAL TARGETS.

DNF-10® (Saccharomyces cerevisiae Peptide Complex)

Dose: 500 mg Role: Satiety Signaling — Neuropeptide Y Modulation & Ghrelin Balance

DNF-10® is a clinically studied complex of small bioactive peptides derived from Saccharomyces cerevisiae, designed to support healthy satiety signaling through two complementary neuroendocrine mechanisms.*

Neuropeptide Y (NPY) is one of the most potent appetite-stimulating signals in the hypothalamus. DNF-10® supports healthy NPY expression, helping modulate the hunger signals that drive caloric intake between meals.* It also supports healthy ghrelin levels — the primary "hunger hormone" produced in the stomach that rises before meals and falls after eating — helping support appetite control and healthy caloric balance.*

By addressing the neuroendocrine signals that govern appetite before food is consumed, rather than downstream metabolic processes after it, DNF-10® provides a uniquely upstream contribution to the formula.*

GlucoVantage® (Dihydroberberine)

Dose: 200 mg Role: AMPK Activation & Intracellular Glucose Metabolism

GlucoVantage® is the most bioavailable form of berberine available — delivering dihydroberberine (DHB), the active metabolite that conventional berberine must first be converted into before absorption. This bypass means GlucoVantage® achieves up to 5x greater bioavailability at lower doses and with significantly improved gastrointestinal tolerability compared to standard berberine.*

DHB supports AMPK-related metabolic signaling — the intracellular energy-sensing pathway that governs glucose uptake, fatty acid oxidation, lipid metabolism, and mitochondrial efficiency.* It also supports healthy insulin signaling and glucose regulation — complementing the upstream appetite support of DNF-10® with downstream cellular glucose processing.*

Also featured in GlucoPrime™ — when metabolic support across both glucose metabolism and post-meal glucose handling are concurrent clinical priorities, the two formulas work through complementary pathways.*

MitoBurn® (L-β-Aminoisobutyric Acid / L-BAIBA)

Dose: 500 mg Role: Exercise-Mimetic Signaling — Fat Browning & Fatty Acid Oxidation

MitoBurn® delivers L-BAIBA (L-β-aminoisobutyric acid) — a myokine classified as an exerkine, a naturally occurring signaling molecule released by working muscle during exercise via the PGC-1α/AMPK cascade. L-BAIBA is increasingly recognized as one of the key molecular messengers through which exercise exerts its metabolic benefits — explaining why it is termed an "exercise mimetic."*

L-BAIBA plasma levels decline with age — not because muscle stops producing it, but because expression of the MRGPRD receptor (L-BAIBA's primary signaling receptor) declines over time. This age-related decline represents a meaningful gap in metabolic signaling that Ignite+ addresses directly.*

MitoBurn® supports metabolic health through three interconnected mechanisms:*

White Adipose Tissue Browning: L-BAIBA supports the conversion of energy-storing white adipose tissue (WAT) into metabolically active brown adipose tissue (BAT) — a process that increases basal caloric expenditure independent of exercise.*

Fatty Acid Oxidation: L-BAIBA supports β-oxidation via the PPARα pathway in the liver — supporting the body's ability to use stored fat as fuel.*

AMPK & Leptin Signaling: L-BAIBA activates AMPK and supports healthy leptin sensitivity — two critical metabolic regulators that decline with age and metabolic stress.*

A 28-day clinical study demonstrated MitoBurn® significantly improved glycogen supercompensation after endurance exercise — an additional benefit for active patients and athletes.*

InnoSlim® (Panax notoginseng + Astragalus membranaceus Extracts)

Dose: 250 mg Role: Dual-Action Glucose Metabolism — Intestinal Absorption + Muscle Uptake Standardized for Astragalosides and Ginsenosides Rg1 and Rb1

InnoSlim® is a patented botanical blend backed by both human and preclinical research for its dual-action approach to healthy glucose metabolism. It addresses glucose at two different points in the metabolic cycle — reducing the amount absorbed from the intestine while simultaneously improving how efficiently cells take it up.*

Intestinal Glucose Reduction: InnoSlim® supports healthy reductions in intestinal glucose absorption — helping moderate the glucose load entering circulation after carbohydrate-containing meals.*

GLUT4 Upregulation: InnoSlim® supports GLUT4 transporter expression in muscle and adipose cells — the primary mechanism through which insulin stimulates glucose uptake into peripheral tissues.* By upregulating GLUT4, it supports more efficient cellular glucose utilization.*

InnoSlim® also supports healthy AMPK activation, healthy adiponectin levels, and balanced insulin signaling — reinforcing GlucoVantage®'s intracellular metabolic signaling through complementary upstream mechanisms.*

Factor21® (Momordica charantia / Bitter Melon Extract)

Dose: 500 mg Role: FGF21 Activation — Longevity Hormone & Energy Expenditure Support A trademark of Verdure Sciences, Inc.

Factor21® is a standardized bitter melon extract designed to support Fibroblast Growth Factor-21 (FGF21) activity — a hepatokine increasingly recognized in longevity medicine for its central role in metabolic homeostasis, energy expenditure regulation, and healthy aging.*

FGF21 is produced primarily in the liver in response to metabolic stress and acts as a systemic regulator of energy balance — stimulating fatty acid oxidation, promoting adiponectin secretion, and supporting healthy mitochondrial function in brown adipose tissue.* FGF21 levels are closely correlated with metabolic flexibility — the ability of cells to switch efficiently between fuel sources.

Factor21® supports FGF21 activity, AMPK activation, healthy insulin efficiency, and healthy energy turnover — contributing to the formula's comprehensive approach to metabolic longevity through a pathway that most metabolic formulas do not address.*

Actiponin® (Gynostemma pentaphyllum Extract, standardized for Damulins A & B)

Dose: 225 mg Role: AMPK Activation & Body Composition Support — 12-Week Clinical Evidence

Actiponin® is a heat-processed Gynostemma pentaphyllum extract standardized for damulins A and B — two unique saponins that directly activate AMPK through a distinct mechanism from GlucoVantage® — providing complementary AMPK support through different molecular targets.*

CalorieBurn GP® (Aframomum melegueta / Grains of Paradise Extract, standardized to 6-Paradol)

Dose: 40 mg Role: Brown Adipose Tissue Thermogenesis Activation

CalorieBurn GP® is a patented extract of Grains of Paradise (Aframomum melegueta) — a member of the ginger family — standardized for 6-paradol and related thermogenic compounds. 6-Paradol activates brown adipose tissue (BAT) thermogenesis through sympathetic nervous system stimulation, supporting healthy caloric expenditure at rest.*

Brown adipose tissue is metabolically unique: unlike white adipose tissue which stores energy, BAT burns calories to generate heat through uncoupling protein activity. BAT activation simultaneously supports healthy caloric expenditure and pulls glucose and fatty acids from the bloodstream — providing downstream benefits for both metabolic rate and glycemic balance.*

Clinical and preclinical evidence demonstrates that Grains of Paradise extract activates BAT thermogenesis and supports whole-body energy expenditure in humans with active BAT, and supports reductions in visceral fat with daily use.*

At 40 mg, CalorieBurn GP® delivers the thermogenic activation benefit through a mechanism entirely distinct from MitoBurn®'s fat browning pathway — BAT thermogenesis (existing brown fat burning calories) versus WAT browning (converting white fat into brown fat) — making them complementary rather than redundant.*