Cardio NAD+

Cardio NAD+ — Advanced Cardiovascular and Vascular Support Formula

KEY SUPPORTED BENEFITS

Cardio NAD+ is formulated to support:*

• Healthy NAD+ metabolism — promoting synthesis and limiting enzymatic degradation*
• Healthy blood pressure and circulatory dynamics*
• Vascular flexibility, endothelial integrity, and glycocalyx health*
• Healthy fibrinolytic activity and balanced platelet function*
• Nitric oxide-mediated vasodilation and healthy vascular signaling*
• Balanced inflammatory response signaling and oxidative stress resilience*
• Healthy lipid metabolism and cardiometabolic balance*
• Healthy blood viscosity and microvascular flow*

Cardiovascular aging is not a single problem. Cardio NAD+ was not built as a single solution.

The vascular changes that accompany aging — declining NAD+ status, reduced endothelial flexibility, glycocalyx degradation, fibrinolytic slowing, increasing blood viscosity, weakening nitric oxide signaling — operate through independent but interconnected pathways. Addressing any one of them in isolation leaves the others unattended.

Cardio NAD+ was formulated to address all of them simultaneously — integrating eight clinically studied ingredients across NAD+ metabolism, vascular signaling, endothelial integrity, lipid balance, fibrinolytic support, and nitric oxide production into a single precision formula for cardiovascular longevity.*

HOW CARDIO NAD+ ADDRESSES CARDIOVASCULAR AGING

Eight Pathways. One Unified Protocol.*

Most cardiovascular supplements address one or two pathways — typically nitric oxide or lipid support. Cardio NAD+ was built around the understanding that cardiovascular aging is a multi-pathway process, and that meaningful longevity support requires addressing the full spectrum of mechanisms:

• NAD+ Metabolism → NAD3® + Niacinamide
• Vascular Signaling → PeptiPump® (ACE modulation)
• Nitric Oxide Production Support → FitNox® (endogenous NO amplification)
• Mitochondrial Energy → CoQ10 with LEO-HB®
• Glycocalyx Integrity → Fucoidan (Mekabu)
• Fibrinolytic Balance → Nattokinase
• Lipid & Cardiometabolic Balance → Citrus Bergamot
• Downstream Longevity Signaling → NAD3® (hallmarks of aging pathways)

THE EIGHT-PATHWAY FORMULA

NAD3® + Niacinamide — Dual-Pathway NAD+ & Cardiometabolic Support

Dose: NAD3® 312 mg + Niacinamide 200 mg

NAD3® is the first nutraceutical ingredient to demonstrate improvement in NAD+ status without relying on a traditional precursor, and the first NAD ingredient to show clinical benefits in humans — validated in the ENHANCE Trial published in the journal Physiologia.*

NAD3® is a precision blend of Wasabi japonica extract, theacrine, and a copper(I)-niacin complex. Unlike conventional NAD+ precursors such as NR or NMN that simply supply raw material, NAD3® works by activating enzymes that support NAD+ conversion from precursors while simultaneously suppressing the enzymatic activity that degrades NAD+ — a dual-mechanism approach that addresses both sides of the NAD+ equation.*

Clinical Evidence — ENHANCE Trial (12 weeks, human, published in Physiologia):*

• 19% reduction in VLDL versus placebo*
• 16% reduction in LDL-C versus placebo*
• 12% reduction in total cholesterol versus placebo*
• Significant improvement in NAD+/NADH ratio — without an appreciable NAD+ precursor dose*
• Beneficial changes in additional markers related to cardiometabolic health and hallmarks of aging*

NAD3® supports downstream longevity signaling pathways while addressing both the synthesis and degradation sides of healthy NAD+ status — a meaningfully different mechanism from precursor-only approaches.*

Niacinamide (200 mg) enhances this through the NAD+ salvage pathway — the recycling system that reclaims NAD+ from metabolic byproducts. Research confirms a single 200 mg dose of niacinamide is sufficient to modulate NAD+ salvage and related metabolic pathways in humans, with decades of human safety data supporting long-term use.*

PeptiPump® — AI-Discovered Peptides for Vascular Signaling

PeptiPump® is a network of bioactive peptides identified within lentil protein hydrolysate by Nuritas's Magnifier™ AI platform — screened specifically for angiotensin-converting enzyme (ACE) inhibitory activity and confirmed to survive gastrointestinal digestion, reaching circulation in active form.*

In the renin-angiotensin system, ACE converts angiotensin I to angiotensin II — one of the most potent endogenous vasoconstrictors in the body. By supporting healthy ACE modulation, PeptiPump® promotes smooth vascular muscle relaxation, healthy circulatory dynamics, and improved oxygen and nutrient delivery to tissues — through a complementary mechanism to nitrate and citrulline pathways, not a duplicative one.*

PeptiPump® also carries predicted activity across glucose uptake enhancement and a broad anti-inflammatory profile relevant to exercise-induced vascular stress — making it relevant for both cardiovascular longevity and active patient populations.*

Powered by Nuritas — PeptiPump® is an AI-discovered ingredient available in select Healthgevity practitioner formulas. [Learn more about our Nuritas partnership →]

Coenzyme Q10 with LEO-HB® Technology — Cellular Energy & Antioxidant Defense

CoQ10 is essential for mitochondrial ATP synthesis and serves as a key membrane-bound antioxidant — both functions critical to cardiovascular cellular health. The heart is one of the most metabolically active tissues in the body, with among the highest CoQ10 density of any organ. CoQ10 levels decline with age and are further reduced by statin therapy, creating a meaningful nutritional gap in many cardiovascular longevity patients.*

The challenge with conventional CoQ10 is bioavailability. As a lipophilic compound, CoQ10 is poorly absorbed in standard oral forms.

Cardio NAD+ uses CoQ10 enhanced by LEO-HB® solid-state dispersion technology — a novel approach that transforms CoQ10 into a highly efficient free-flowing powder that disperses readily, dramatically improving solubility and cellular delivery compared to conventional CoQ10.*

Fucoidan from Mekabu (Undaria pinnatifida) — Glycocalyx & Endothelial Integrity

The vascular glycocalyx — a complex carbohydrate layer coating the inner surface of blood vessel endothelial cells — plays a central role in vascular function. It regulates microvascular blood flow, modulates inflammatory signaling, and serves as a critical interface between the bloodstream and vessel wall. Glycocalyx degradation is increasingly recognized as an early and important contributor to cardiovascular aging and endothelial dysfunction.*

Fucoidan, sourced from the sporophyll of Undaria pinnatifida (mekabu wakame) and standardized to 85% fucoidan content, supports glycocalyx regeneration and endothelial barrier integrity. Research demonstrates fucoidan's ability to promote glycocalyx repair and renewal — helping preserve endothelial function and supporting vascular elasticity over time.

FitNox® — Triple Botanical Nitric Oxide Amplifier

FitNox® is a patented botanical blend of moringa, pomegranate, and black ginger, formulated using Polar-Nonpolar-Sandwich (PNS) technology to support sustained nitric oxide production through endogenous enzymatic activation — without relying on nitrates.*

Nitric oxide is the primary endogenous vasodilator — signaling smooth vascular muscle to relax, widening vessel diameter, and supporting healthy blood pressure and circulation. NO signaling declines with age and metabolic stress, contributing to vascular stiffening and reduced circulatory efficiency.*

Clinical Evidence — FitNox®:*

• Significantly elevated nitric oxide biomarkers in clinical testing*
• Rapid onset: measurable increases in nitrate and nitrite levels within one hour*
• Sustained effect: maintained for up to ten hours*
• 22-day study demonstrated improved physical endurance, reduced lactate dehydrogenase (LDH), and reduced malondialdehyde (MDA) in healthy adult males*
• No nitrate dependency — works through enzymatic NO synthesis rather than nitrate conversion*

Nattokinase — Fibrinolytic & Circulatory Support

Nattokinase is a serine protease enzyme derived from Bacillus subtilis fermentation of soybeans. It supports healthy fibrinolytic activity — the system that maintains balanced fibrin turnover in circulation — and has been studied for its role in supporting healthy blood viscosity, platelet balance, and vascular flow dynamics.*

Citrus Bergamot — Lipid & Cardiometabolic Balance

Citrus Bergamot, sourced from Calabria in southern Italy, contains a unique profile of polyphenolic compounds — including brutieridins and melitidin — with a well-documented capacity to support lipid metabolism and cardiometabolic balance.*

Clinical evidence demonstrates bergamot polyphenols can support healthy cholesterol ratios, triglyceride levels, and HDL function — complementing the cardiometabolic signaling of NAD3® in the formula and providing broad-spectrum lipid balance support.*

Bergamot polyphenols also support endothelial function and balanced inflammatory response signaling — addressing cardiometabolic health from both the lipid metabolism and vascular integrity directions simultaneously.*

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