Longevity

Longevity— Advanced Muscle Health, Performance & Recovery Support

Muscle loss is not an inevitable consequence of aging. It is a biological process — and biology has mechanisms that can be supported.*

After the age of 30, adults lose approximately 3–8% of muscle mass per decade, accelerating after 60. This is not simply a matter of reduced protein intake. The underlying drivers are more fundamental: declining mTOR sensitivity to anabolic signals, accumulation of senescent cells in muscle tissue that impair regeneration, reduced vascular delivery of nutrients and oxygen to working muscle, and progressive loss of the anabolic response to leucine that characterized younger muscle physiology.

Longevity was built around this biology. Four clinically studied, patented ingredients — each addressing a distinct and non-redundant mechanism in the muscle aging equation — in a single daily formula designed for practitioners supporting muscle longevity, performance, and recovery across the lifespan.*

KEY SUPPORTED BENEFITS

Longevity is formulated to support:

• Healthy muscle protein synthesis and lean muscle maintenance*
• Muscle strength, power, and functional performance across age groups*
• Senescent cell clearance in muscle tissue — the longevity mechanism most muscle formulas miss*
• Muscle energy production and mitochondrial efficiency during exercise*
• Post-exercise recovery, reduced muscle fatigue, and faster strength restoration*
• Healthy vascular tone, blood flow, and muscle oxygenation during activity*
• Nutrient absorption and gut–muscle axis integrity*
• Bone density support — relevant particularly for perimenopausal and aging populations*

THE FOUR-PATHWAY MUSCLE LONGEVITY SYSTEM

• Muscle Protein Synthesis & mTOR → PeptiStrong® (3 human trials · 19.7% strength gain)
• Senolytic Muscle Renewal → Senactiv® (senescent cell clearance · 47% citrate synthase increase)
• Vascular Performance & ACE Support → PeptiPump® (AI-discovered · lentil peptides)
• Gut–Muscle Axis & Absorption → AstraGin® (nutrient transporter up-regulation)

THE FORMULA:

PeptiStrong® (Vicia faba / Fava Bean Protein Hydrolysate)

Dose: 2.4 g Role: Muscle Protein Synthesis, Strength, Recovery & Longevity Signaling Discovered by Nuritas Magnifier™ AI Platform

PeptiStrong® is a network of cell-signaling peptides identified within fava bean protein hydrolysate by Nuritas's Magnifier™ AI platform — screened from over 2 million candidate peptide sequences and selected specifically for their ability to activate mTOR-related muscle protein synthesis pathways, survive gastrointestinal digestion intact, and reach muscle tissue in biologically active form.*

The clinical story behind PeptiStrong® is one of the strongest in the practitioner muscle longevity space — three completed, peer-reviewed human clinical trials at the 2.4 g dose used in this formula:*

Study 1 — Immobilization & Muscle Protein Synthesis (Maastricht University, published in The Journal of Nutrition, 2023):*

• 30 healthy young men underwent short-term leg immobilization followed by remobilization
• PeptiStrong® performed equivalently to milk protein in preserving muscle mass during immobilization
• PeptiStrong® significantly outperformed milk protein in muscle protein synthesis rate during the remobilization and recovery phase
• This is a critical finding: plant-derived peptides at 2.4 g outperforming the gold-standard animal protein for muscle recovery*

Study 2 — Strength Recovery & Fatigue (Nutrients, 2023):*

• Healthy male population with exercise-induced muscle damage (DOMS protocol)
• PeptiStrong® significantly improved strength recovery compared to placebo
• Significant reduction in muscle fatigue following exercise
• Significant suppression of plasma myostatin — the protein that inhibits muscle growth — compared to placebo
• Researchers concluded PeptiStrong® "significantly improves strength recovery and restoration, reduces fatigue, and positively modulates alterations in markers related to muscle homeostasis"*

Study 3 — Strength, Bone Density & Endurance (Nuritas, 2024, male and female population ages 19–40):*

• 56-day supplementation with 2.4 g PeptiStrong® or placebo
• 19.7% greater increase in muscle strength versus placebo, achieved faster than placebo
• 1% increase in bone density after only 56 days — a clinically meaningful finding for perimenopausal women and aging patients*
• Improvements in muscular endurance alongside strength gains
• Results demonstrated across a mixed male and female population

Comparative data (Nuritas, 2024): PeptiStrong® has been shown to be as effective as leucine at 25% of the typical leucine dose, 60% more effective than HMB at half the usual dose, and to match creatine in ATP synthesis with 5x superior mTOR upregulation.*

Key mechanisms:*

• mTOR pathway activation supporting muscle fiber regeneration and protein synthesis*
• Myostatin suppression — reducing the primary brake on muscle growth*
• AMPK activation supporting mitochondrial energy metabolism*
• Type I and Type II muscle fiber support — endurance and power simultaneously*

Powered by Nuritas — the only AI-discovered muscle longevity peptide network with three completed human clinical trials. [Learn more about our Nuritas partnership →]

Senactiv® (Panax notoginseng Root + Rosa roxburghii Fruit Extracts)

Dose: 100 mg Role: Senolytic Muscle Renewal — Clearing Senescent Cells for New Muscle Generation by NuLiv Science · US Patent No. 10,806,764

Senactiv® is the first and only natural phytocompound backed by human studies demonstrating its ability to slow the aging process in muscle tissue through the clearance of senescent cells — making it a genuinely unique ingredient at the intersection of longevity science and exercise performance.*

What senescent muscle cells are and why they matter: As muscles undergo repeated cycles of stress and recovery, a proportion of muscle cells enter a state of cellular senescence — losing the ability to divide or regenerate while simultaneously secreting pro-inflammatory signals (SASP) that impair the function of surrounding healthy cells. The accumulation of senescent muscle cells with age is a primary driver of declining muscle quality, reduced exercise capacity, and impaired recovery — independent of protein intake or training volume.*

Senactiv® addresses this directly. In a key human clinical study, 9 of 12 participants who supplemented with Senactiv® showed complete elimination of senescent muscle cells following high-intensity interval training. The proposed mechanism involves activation of phagocytic macrophages that clear senescent cells from muscle tissue — allowing new, healthy muscle cells with greater mitochondrial density, ATP production capacity, and glycogen storage potential to regenerate in their place.*

Clinical Evidence — Human and Preclinical Studies (4 human clinical trials, 2 in-vivo studies):*

• 47% increase in citrate synthase activity — a direct marker of mitochondrial energy production capacity in muscle*
• 2.7x greater muscle glycogen accumulation compared to control following exercise*
• Significant improvement in endurance performance and time to exhaustion during high-intensity interval training*
• Complete elimination of senescent muscle cells demonstrated in 9 of 12 human subjects post-HIIT*
• Preservation of insulin receptor and muscle glycogen transporter function during high-intensity exercise*
• Significant reduction in inflammatory and oxidative biomarkers post-exercise*

The relevance of Senactiv® to a longevity-focused practitioner audience extends beyond exercise performance. Senescent cell accumulation in muscle tissue is one of the hallmarks of musculoskeletal aging — Senactiv®'s mechanism of supporting senescent cell clearance places it in the same conceptual category as the senolytic compounds in Rejuvenate, but specifically targeting muscle tissue through exercise-activated pathways.*

PeptiPump® (Lentil Protein Hydrolysate)

Dose: 200 mg Role: ACE-Modulating Vascular Support & Muscle Oxygenation During Exercise Discovered by Nuritas Magnifier™ AI Platform

PeptiPump® is a network of bioactive peptides identified within lentil protein hydrolysate by Nuritas's Magnifier™ AI platform — specifically screened for angiotensin-converting enzyme (ACE) inhibitory activity and confirmed to survive gastrointestinal digestion, reaching circulation in biologically active form.*

By supporting healthy ACE modulation within the renin-angiotensin system, PeptiPump® promotes smooth vascular muscle relaxation, healthy circulatory dynamics, and improved oxygen and nutrient delivery to working muscle during exercise.* The result is better muscle oxygenation, improved nutrient delivery to muscle tissue during training, and support for the vascular environment that determines both performance output and recovery speed.*

PeptiPump® operates through a mechanism entirely distinct from mTOR signaling (PeptiStrong®) and senolytic renewal (Senactiv®) — making it a non-redundant addition to the formula that closes the vascular loop in the muscle longevity equation.*

Also featured in Cardio NAD+ for its cardiovascular longevity applications. In Longevity, PeptiPump® serves specifically as the vascular performance and muscle oxygenation layer during exercise and recovery.*

Powered by Nuritas. [Learn more about our Nuritas partnership →]

AstraGin® (Astragalus membranaceus + Panax notoginseng Root Extracts)

Dose: 50 mg Role: Nutrient Absorption & Gut–Muscle Axis Integrity 

AstraGin® is a patented botanical blend with an established research profile for supporting intestinal nutrient absorption through upregulation of key nutrient transporter proteins in the intestinal wall — including the transporters responsible for absorbing amino acids such as arginine and leucine, the primary substrates of muscle protein synthesis.*

In Longevity, AstraGin® serves two roles. First, it supports the absorption and bioavailability of PeptiStrong®'s active peptide fractions — ensuring that the clinical doses established in the human trials are effectively absorbed and delivered to muscle tissue. Second, it supports gut barrier integrity and healthy inflammatory signaling in the intestinal environment — the gut-muscle axis foundation that determines how efficiently nutritional inputs are converted to muscle outputs.*

AstraGin® is also featured in GlucoPrime™ and dailyDIM+™ where its absorption-enhancing role is similarly critical. NuLiv Science's pharmaceutical-grade extraction process is what differentiates Senactiv® and AstraGin® from generic Panax notoginseng extracts.*

THE MUSCLE LONGEVITY DISTINCTION

Why Longevity Is Different From Standard Protein and Muscle Supplements

Conventional muscle supplements — whey protein, creatine, leucine, HMB — work primarily at the substrate and energy level: providing raw materials and energy currency for muscle synthesis. They are valuable but they do not address the biological barriers that accumulate with age and progressively limit the effectiveness of those substrates.

Longevity addresses the biology that limits response to protein and exercise in aging muscle:

PeptiStrong® restores the mTOR anabolic signal — specifically the declining sensitivity to leucine that characterizes older muscle physiology, allowing the body to use available protein more efficiently.*

Senactiv® removes the senescent cell burden — the accumulated dysfunctional cells that impair muscle regeneration and create an inflammatory microenvironment that resists recovery.*

PeptiPump® optimizes the vascular delivery of nutrients to muscle — ensuring that what is available in the bloodstream actually reaches working tissue.*

AstraGin® optimizes what is absorbed from the gut — ensuring the formula's active ingredients reach circulation at the concentrations that matter.*

This is not a protein supplement. It is a systems-level muscle longevity formula — designed for patients for whom the barriers to muscle health are biological, not just nutritional.*

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