DailyDIM+™

DailyDIM+™ — Advanced Support for Hormone Balance and Cellular Detoxification

Healthy estrogen metabolism is not a single step. DailyDIM+™ was designed to support all three.*

Most hormone health supplements focus on one pathway — typically phase I conversion of estrogens into favorable metabolites. DailyDIM+™ was formulated around the understanding that healthy hormone metabolism requires supporting the full sequence: converting estrogen into beneficial metabolites, preparing those metabolites for elimination through phase II detoxification, and ensuring they are actually excreted rather than reabsorbed from the gut.*

Three complementary mechanisms. One precision daily formula. Formulated for both men and women.*

KEY SUPPORTED BENEFITS

DailyDIM+™ is formulated to support:*

• Healthy estrogen metabolism and favorable metabolite ratios (2-OH:16α-OH)*
• Phase I and phase II liver detoxification pathways*
• Healthy beta-glucuronidase balance to support estrogen elimination*
• Nrf2-mediated cellular antioxidant defense and cytoprotective signaling*
• Balanced androgen-estrogen ratios in both men and women*
• Liver function and healthy metabolic clearance pathways*
• Nutrient absorption and bioavailability through AstraGin® and Ioniplex®*

THE THREE-PHASE HORMONE DETOXIFICATION SYSTEM

Why This Formula Is Different:

Understanding how DailyDIM+™ works requires understanding how estrogen is actually metabolized — and where things can go wrong.

Phase I — Estrogen Conversion (Hydroxylation) In phase I liver detoxification, estrogen is hydroxylated into one of three metabolite pathways: 2-hydroxyestrone (2-OHE1), 4-hydroxyestrone (4-OHE1), or 16α-hydroxyestrone (16α-OHE1). The 2-OH pathway is generally considered the favorable route — producing metabolites with weaker estrogenic activity. The 4-OH and 16α-OH pathways produce more potent, potentially problematic metabolites. Supporting the shift toward 2-hydroxylation is the primary goal of DIM supplementation.*

Phase II — Glucuronidation and Conjugation Once hydroxylated, estrogen metabolites undergo phase II detoxification — primarily glucuronidation, where the liver attaches glucuronic acid to the metabolite, rendering it water-soluble and prepared for excretion via bile or urine. This is where Calcium-D-Glucarate and sulforaphane play their critical roles, supporting the enzymatic activity that completes this preparation step.*

Phase III — Elimination (Preventing Reabsorption) This is the step most hormone supplement formulas miss entirely. Even after the liver has successfully glucuronidated estrogen metabolites, they still travel through the intestines on their way out. In the gut, an enzyme called beta-glucuronidase — produced by certain gut bacteria — can reverse the glucuronidation process, cleaving the glucuronic acid bond and freeing the estrogen metabolite to be reabsorbed into circulation through enterohepatic recirculation.*

Calcium-D-Glucarate inhibits beta-glucuronidase activity, ensuring glucuronidated estrogens remain bound and are eliminated rather than recycled. Without this step, the liver's phase II work can be undone in the gut.*

DailyDIM+™ addresses all three phases. Most formulas address one.*

THE FIVE-INGREDIENT FORMULA

DIM (Diindolylmethane)

Dose: 300 mg Role: Phase I Estrogen Metabolism Support

DIM is a naturally occurring phytonutrient derived from indole-3-carbinol (I3C), produced during digestion of cruciferous vegetables including broccoli, cauliflower, kale, and Brussels sprouts. As an active metabolite of I3C, DIM is more bioavailable and more targeted in its activity than its precursor.

DIM's primary mechanism is support of cytochrome P450 enzyme activity in the liver — specifically CYP1A1 and CYP1A2 — which drive the 2-hydroxylation of estrogen toward the 2-OH pathway and away from the 4-OH and 16α-OH pathways.* By promoting a more favorable 2-OH:16α-OH ratio in urinary estrogen metabolites, DIM supports healthier estrogen signaling balance.*

DIM also supports healthy androgen-estrogen balance in both men and women by modulating aromatase activity and SHBG levels — making it relevant not only for women navigating hormonal fluctuation but also for men concerned with estrogen balance in the context of healthy testosterone metabolism.*

Calcium-D-Glucarate

Dose: 1,000 mg Role: Phase II Glucuronidation Support & Beta-Glucuronidase Inhibition

Calcium-D-Glucarate is the calcium salt of D-glucaric acid — found naturally in cruciferous vegetables, oranges, and apples — metabolized in the body to D-glucaro-1,4-lactone, one of the most potent natural inhibitors of beta-glucuronidase.*

Its primary mechanism works at the gut level: by inhibiting beta-glucuronidase, Calcium-D-Glucarate prevents the deconjugation of glucuronidated estrogens and toxins in the intestine — the critical final step that ensures that what the liver has processed for elimination is actually eliminated rather than reabsorbed.*

This mechanism is particularly important because enterohepatic recirculation of estrogen can meaningfully increase effective estrogen exposure even when phase I metabolism is well-supported — a gap that DIM alone cannot address.*

Activated BroccoRaphanin™

Dose: 150 mg (Broccoli Seed Concentrate + Myrosinase Enzyme) Role: Nrf2-Mediated Phase II Detoxification & Cellular Antioxidant Defense

Activated BroccoRaphanin™ delivers sulforaphane glucosinolate (SGS) from broccoli seed concentrate, standardized for consistent glucoraphanin content, paired with myrosinase enzyme — the specific enzyme required to convert glucoraphanin into bioactive sulforaphane.* This pairing is critical: cooking and processing destroy myrosinase activity in most broccoli-based foods and supplements, meaning glucoraphanin consumed without myrosinase produces little active sulforaphane. Activated BroccoRaphanin™ preserves and delivers both.*

Sulforaphane is widely recognized as one of the most potent known activators of the Nrf2 (Nuclear factor erythroid 2-related factor 2) transcription pathway — the body's master switch for phase II detoxification enzyme induction and antioxidant defense.* When sulforaphane modifies Keap1 — its molecular target — Nrf2 translocates to the nucleus, where it binds the Antioxidant Response Element (ARE) and upregulates over 200 cytoprotective genes.* These include:

• NQO1 (NAD(P)H:quinone oxidoreductase 1) — detoxifies reactive quinones*
• Glutathione S-transferases (GSTs) — facilitate toxin binding and elimination*
• Gamma-glutamylcysteine ligase — supports glutathione synthesis*
• Heme oxygenase-1 (HO-1) — supports anti-inflammatory cellular defense*

Sulforaphane also supports healthy estrogen processing through independent mechanisms, including Nrf2-mediated upregulation of detoxification enzymes involved in estrogen metabolism — complementing DIM's phase I activity with upstream cellular defense support.*

Ioniplex® (Fulvic Ionic Mineral Complex)

Dose: 100 mg Role: Nutrient Transport & Cellular Energy Support

Ioniplex® is a standardized fulvic mineral complex that supports nutrient transport into cells, mitochondrial efficiency, and cellular detoxification.* Fulvic acid acts as a natural electrolyte and electron carrier, enhancing cellular uptake of minerals and bioactive compounds and supporting the energy production pathways that drive detoxification processes. In DailyDIM+™, Ioniplex® serves as the cellular delivery and energy support layer — ensuring that the active ingredients have the intracellular environment they need to function effectively.

AstraGin® (Astragalus membranaceus and Panax notoginseng Root Extracts)

Dose: 50 mg Role: Nutrient Absorption & Bioavailability Enhancement

AstraGin® is a patented botanical blend with a well-established research profile for supporting intestinal nutrient absorption through upregulation of key nutrient transporter proteins in the intestinal wall.* It supports the absorption and bioavailability of amino acids, vitamins, and bioactive compounds — ensuring the active ingredients in DailyDIM+™ are efficiently absorbed and reach their target tissues at meaningful concentrations.*

AstraGin® also supports gut barrier integrity and healthy inflammatory response signaling in the intestinal environment — complementing Calcium-D-Glucarate's gut-level activity and supporting the overall foundation for effective detoxification and elimination.*

WHO IS DAILYDIM+™ FOR?

DailyDIM+™ was formulated for both men and women. Healthy estrogen metabolism is relevant across patient populations:

For women: Supporting favorable estrogen metabolite ratios, phase II clearance, and elimination is relevant across reproductive years, perimenopause, and beyond — wherever estrogen metabolism, hormonal fluctuation, or detoxification support is a clinical priority.*

For men: DIM supports healthy androgen-estrogen balance, including modulation of aromatase activity and SHBG — relevant for men concerned with estrogen balance in the context of healthy testosterone metabolism and metabolic health.*

For both: The Nrf2 activation and phase II detoxification support provided by sulforaphane, combined with liver detoxification pathway support from Calcium-D-Glucarate, has broad relevance for any patient where cellular antioxidant defense, environmental toxin clearance, or liver function support is a clinical consideration.*

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